Functional interplay between type I and II interferons is essential to limit influenza A virus-induced tissue inflammation
SA Stifter, N Bhattacharyya, R Pillay, M Flórido… - PLoS …, 2016 - journals.plos.org
Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation
characterized by the influx of myeloid cells and production of proinflammatory cytokines …
characterized by the influx of myeloid cells and production of proinflammatory cytokines …
[HTML][HTML] Type I interferon production enhances susceptibility to Listeria monocytogenes infection
RM O'Connell, SK Saha, SA Vaidya… - The Journal of …, 2004 - ncbi.nlm.nih.gov
Numerous bacterial products such as lipopolysaccharide potently induce type I interferons
(IFNs); however, the contribution of this innate response to host defense against bacterial …
(IFNs); however, the contribution of this innate response to host defense against bacterial …
New insights into type I interferon and the immunopathogenesis of persistent viral infections
Highlights•IFN-I simultaneously drives critical antiviral and immunomodulatory functions
during viral persistence.•IFN-I drives many of the immune dysfunctions associated with …
during viral persistence.•IFN-I drives many of the immune dysfunctions associated with …
Type I interferon in chronic virus infection and cancer
Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity
EM Eshleman, LL Lenz - Frontiers in immunology, 2014 - frontiersin.org
Type I interferons (IFNs) were first described for their ability to protect the host from viral
infections and may also have beneficial effects under specific conditions within some …
infections and may also have beneficial effects under specific conditions within some …
Regulation of immune cell homeostasis by type I interferons
Although initially identified and best characterized for their role in innate antiviral defence,
type I interferons (IFN-I) are also known to have an important impact on the adaptive immune …
type I interferons (IFN-I) are also known to have an important impact on the adaptive immune …
IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity
Y Karimi, EC Giles, F Vahedi, MV Chew… - Innate …, 2020 - journals.sagepub.com
Type I IFN holds a critical role in host defence, providing protection against pathogenic
organisms through coordinating a pro-inflammatory response. Type I IFN provides additional …
organisms through coordinating a pro-inflammatory response. Type I IFN provides additional …
Type III IFNs: beyond antiviral protection
SV Kotenko, A Rivera, D Parker, JE Durbin - Seminars in immunology, 2019 - Elsevier
The unexpected discovery of a novel family of antiviral mediators, type III IFNs or IFN-λs,
challenged the widely accepted primacy of type I IFNs in antiviral immunity, and it is now …
challenged the widely accepted primacy of type I IFNs in antiviral immunity, and it is now …
Detrimental type I interferon signaling dominates protective AIM2 inflammasome responses during Francisella novicida infection
Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity.
Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however …
Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however …
Pathogenicity of Type I Interferons in Mycobacterium tuberculosis
A Mundra, A Yegiazaryan, H Karsian, D Alsaigh… - International Journal of …, 2023 - mdpi.com
Tuberculosis (TB) is a leading cause of mortality due to infectious disease and rates have
increased during the emergence of COVID-19, but many of the factors determining disease …
increased during the emergence of COVID-19, but many of the factors determining disease …