Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation
characterized by the influx of myeloid cells and production of proinflammatory cytokines …

Numerous bacterial products such as lipopolysaccharide potently induce type I interferons
(IFNs); however, the contribution of this innate response to host defense against bacterial …

Highlights•IFN-I simultaneously drives critical antiviral and immunomodulatory functions
during viral persistence.•IFN-I drives many of the immune dysfunctions associated with …

Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

Type I interferons (IFNs) were first described for their ability to protect the host from viral
infections and may also have beneficial effects under specific conditions within some …

Although initially identified and best characterized for their role in innate antiviral defence,
type I interferons (IFN-I) are also known to have an important impact on the adaptive immune …

Type I IFN holds a critical role in host defence, providing protection against pathogenic
organisms through coordinating a pro-inflammatory response. Type I IFN provides additional …

The unexpected discovery of a novel family of antiviral mediators, type III IFNs or IFN-λs,
challenged the widely accepted primacy of type I IFNs in antiviral immunity, and it is now …

Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity.
Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however …

Tuberculosis (TB) is a leading cause of mortality due to infectious disease and rates have
increased during the emergence of COVID-19, but many of the factors determining disease …