Cows are not mice: The role of cyclic AMP, phosphodiesterases, and adenosine monophosphate‐activated protein kinase in the maintenance of meiotic arrest in …

S Bilodeau‐Goeseels - Molecular reproduction and …, 2011 - Wiley Online Library
Meiotic maturation in mammalian oocytes is initiated during fetal development, and is then
arrested at the dictyate stage–possibly for several years. Oocyte meiosis resumes in …

[HTML][HTML] New approaches regarding the in vitro maturation of oocytes: manipulating cyclic nucleotides and their partners in crime

RC Botigelli, EM Razza, EM Pioltine… - JBRA Assisted …, 2017 - ncbi.nlm.nih.gov
Several discoveries have been described recently (5-10 years) about the biology of ovarian
follicles (oocyte, cumulus cells and granulosa cells), including new aspects of cellular …

Substrate utilization and maturation of cumulus cell-enclosed mouse oocytes: evidence that pyruvate oxidation does not mediate meiotic induction

SM Downs, FD Houghton, PG Humpherson… - …, 1997 - rep.bioscientifica.com
This study was performed to address the possible role of pyruvate in meiotic induction in
mouse oocytes. Cumulus cell-enclosed oocytes from primed, immature mice were cultured …

Effects of glucose metabolism during in vitro maturation on cytoplasmic maturation of mouse oocytes

HL Xie, YB Wang, GZ Jiao, DL Kong, Q Li, H Li… - Scientific reports, 2016 - nature.com
Although there are many reports on the effect of glucose metabolism on oocyte nuclear
maturation, there are few studies on its effect on ooplasmic maturation. By manipulating …

Meiotic arrest maintained by cAMP during the initiation of maturation enhances meiotic potential and developmental competence and reduces polyspermy of IVM/IVF …

T Somfai, K Kikuchi, A Onishi, M Iwamoto, D Fuchimoto… - Zygote, 2003 - cambridge.org
We investigated effects of invasive adenylate cyclase (iAC), 3-isobutyl-1-methylxanthine
(IBMX) and dibutyryl cyclic AMP (dbcAMP) on porcine oocyte in vitro maturation (IVM), in …

Effects of adenosine monophosphate‐activated kinase activators on bovine oocyte nuclear maturation in vitro

S Bilodeau‐Goeseels, M Sasseville… - Molecular …, 2007 - Wiley Online Library
The purpose of this study was to examine the effects of an activator of AMPK (5‐
aminoimidazole‐4‐carboxamide 1‐β‐D‐ribofuranoside (AICAR)) on bovine oocyte nuclear …

Effect of 5-aminoimidazole-4-carboxamide ribonucleoside on the mitochondrial function and developmental ability of bovine oocytes

S Takeo, T Abe, K Shirasuna, T Kuwayama, H Iwata - Theriogenology, 2015 - Elsevier
Oocyte nuclear maturation depends on sufficient energy supply through oxidative
phosphorylation and β-oxidation. AMP-activated protein kinase (AMPK) is an energy sensor …

Uptake and metabolism of adenosine mediate a meiosis‐arresting action on mouse oocytes

SM Downs - Molecular Reproduction and Development …, 1999 - Wiley Online Library
This study was carried out to evaluate the possible role of adenosine uptake and
metabolism in mediating the inhibitory actions of this nucleoside on spontaneous mouse …

Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca2+ entry

LY Zhang, M Lin, Z Qingrui, W Zichuan… - Cell …, 2021 - Wiley Online Library
Objectives The alteration of bioenergetics by oocytes in response to the demands of various
biological processes plays a critical role in maintaining normal cellular physiology. However …

A follicular fluid component prevents gonadotropin reversal of cyclic adenosine monophosphate‐dependent meiotic arrest in murine oocytes

SM Downs, JJ Eppig - Gamete research, 1985 - Wiley Online Library
The effects of the putative maturation inhibitor in porcine follicular fluid on
gonadotropinstimulated reversal of cyclic adenosine monophosphate (cAMP)‐maintained …