Defective expression and function of the cystic fibrosis transmembrane conductance
regulator (CFTR) in cystic fibrosis (CF) airway epithelial cells are associated with airway …

Cystic fibrosis (CF) is both the most common and most lethal genetic disease in the
Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane …

Background Studies in cystic fibrosis (CF) generally focus on inflammation present in the
airway lumen. Little is known about inflammation occurring in the airway wall, the site …

Individuals with cystic fibrosis (CF) suffer progressive airway inflammation, infection and
lung damage. Airway inflammation and infection are present from early in life, often before …

Controversy exists over whether the lower airway inflammation that characterizes cystic
fibrosis (CF) is initiated primarily by the genetic defect. To determine if inflammation …

Cystic fibrosis (CF), an autosomal genetic disorder caused by the dysfunction of the cystic
fibrosis transmembrane conductance regulator (CFTR) protein, is characterized by mucus …

Abnormalities in mucus properties and clearance make a major contribution to the pathology
of cystic fibrosis (CF). Our aim was to test the hypothesis that the defects in CF mucus are a …

Persistent lower airway infection with inflammation is the major cause of morbidity and
mortality in cystic fibrosis. This review examines the recent advances in the understanding of …

Background Molecular techniques have uncovered vast numbers of organisms in the cystic
fibrosis (CF) airways, the clinical significance of which is yet to be determined. The aim of …

Airway inflammation is an important component of cystic fibrosis (CF) lung disease. To
determine whether this begins early in the illness, before the onset of infection, we examined …