Cell-to-cell spreading of HIV-1 in myeloid target cells escapes SAMHD1 restriction
Dendritic cells (DCs) and macrophages as well as osteoclasts (OCs) are emerging as target
cells of HIV-1 involved in virus transmission, dissemination, and establishment of persistent …
cells of HIV-1 involved in virus transmission, dissemination, and establishment of persistent …
Revising the role of myeloid cells in HIV pathogenesis
A Aggarwal, S McAllery, SG Turville - Current HIV/AIDS Reports, 2013 - Springer
Lentiviruses are characterized by their ability to infect resting cells, such as CD4 T cells,
macrophages and dendritic cells (DC). Cells of myeloid lineage, which herein we include …
macrophages and dendritic cells (DC). Cells of myeloid lineage, which herein we include …
Moderate restriction of macrophage-tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages
K Taya, EE Nakayama, T Shioda - PloS one, 2014 - journals.plos.org
Macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains are able to grow to
high titers in human monocyte-derived macrophages. However, it was recently reported that …
high titers in human monocyte-derived macrophages. However, it was recently reported that …
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+T-cells
B Descours, A Cribier, C Chable-Bessia, D Ayinde… - Retrovirology, 2012 - Springer
Abstract Background Quiescent CD4+ T lymphocytes are highly refractory to HIV-1 infection
due to a block at reverse transcription. Results Examination of SAMHD1 expression in …
due to a block at reverse transcription. Results Examination of SAMHD1 expression in …
Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1
N Ruffin, V Brezar, D Ayinde, C Lefebvre… - Aids, 2015 - journals.lww.com
Objectives: HIV-1 replication depends on the state of cell activation and division. It is
established that SAMHD1 restricts HIV-1 infection of resting CD4+ T cells. The modulation of …
established that SAMHD1 restricts HIV-1 infection of resting CD4+ T cells. The modulation of …
Immune activation influences samhd1 expression and Vpx-mediated SAMHD1 degradation during chronic HIV-1 infection
W Fu, C Qiu, M Zhou, L Zhu, Y Yang, C Qiu, L Zhang… - Scientific Reports, 2016 - nature.com
SAMHD1 restricts human immunodeficiency virus type 1 (HIV-1) replication in myeloid cells
and CD4+ T cells, while Vpx can mediate SAMHD1 degradation to promote HIV-1 …
and CD4+ T cells, while Vpx can mediate SAMHD1 degradation to promote HIV-1 …
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells
I Puigdomènech, N Casartelli, F Porrot… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT SAMHD1 is a viral restriction factor expressed in dendritic cells and other cells,
inhibiting infection by cell-free human immunodeficiency virus type 1 (HIV-1) particles …
inhibiting infection by cell-free human immunodeficiency virus type 1 (HIV-1) particles …
[HTML][HTML] Incomplete suppression of HIV-1 by SAMHD1 permits efficient macrophage infection
T Plitnik, ME Sharkey, B Mahboubi, B Kim… - Pathogens & …, 2018 - ncbi.nlm.nih.gov
Background: Sterile alpha motif and histidine/aspartic acid domain-containing protein
(SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing …
(SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing …
SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T Cells
JM Antonucci, SH Kim, C St. Gelais, S Bonifati… - Journal of …, 2018 - Am Soc Microbiol
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts human
immunodeficiency virus type 1 (HIV-1) replication in nondividing cells by degrading …
immunodeficiency virus type 1 (HIV-1) replication in nondividing cells by degrading …
Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
B Mahboubi, C Gavegnano, DH Kim, RF Schinazi… - Retrovirology, 2018 - Springer
Background SAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-
1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells …
1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells …