Natural killer (NK) cells have the dual ability to produce pro-inflammatory (IFNγ) and anti-
inflammatory (IL-10) cytokines during systemic infection, which points to their crucial role …

Surviving infection represents a balance between the proinflammatory responses needed to
eliminate the pathogen, and anti-inflammatory signals limiting damage to the host. IL-10 is a …

Natural Killer (NK) cells boost immune defense via their cytolytic activity and their capacity to
produce interferon-γ. Now Perona-Wright et al.(2009), in this issue of Cell Host & Microbe …

Natural killer (NK) cells are large granular lymphocytes largely recognized for their
importance in tumour surveillance and the host response to viral infections. However, as the …

Natural killer (NK) cells have antitumor, antiviral, and antibacterial functions, and efforts are
being made to manipulate them in immunotherapeutic approaches. However, their …

The dysregulated sepsis-induced cytokine storm evoked during systemic infection consists
of biphasic and interconnected pro-and anti-inflammatory responses. The contrasting …

It is well established that IL-18R-and toll-like receptor (TLR)-mediated signalings share a
common signal pathway mediated by signal adaptor, MyD88, and that IL-18 synergizes with …

The combination of interleukin (IL)-18 and IL-12 (IL-18+ IL-12) potently stimulates natural
killer (NK) cells, triggering an innate immune response to infections and cancers. Strategies …

Natural killer (NK) cells are an early source of immunoregulatory cytokines during the innate
immune response to viruses, bacteria, and parasites. NK cells provide requisite IFN‐γ to …

First described 40 years ago, natural killer (NK) cells represent the founding members of the
innate lymphoid cell (ILC) family. They were initially defined by their ability to kill cancer cells …