Figure 2. Various monomer units present in eumelanins. I: 5, 6DHI unit, C/N ratio= 8; II: 5,
6DHI2C unit, C/N ratio= 9; III: pyrrole unit, C/N ratio= 6; IV: pyrrolc-2-carboxylic acid unit, C/N …

ELANIN PIGMENTATION has aroused the curiosity and attention of man since the beginning
of recorded history. This interest stems in part from the social, protective and cosmetic …

A quantitative radiometric assay utilising incorporation of 14C from labelled precursors as a
measure of melanin formation by human brain in vitro is described. The assay was validated …

I. Since the initiation in 1837 of research on the melanotic pigment of the skin, general
agreement has been reached on only a few points. M. reviews these results and considers …

Melanin was measured in various parts of the rat brain by a spectrophotofluorometric assay.
This method could detect natural, Sepia melanin as well as melanin synthesized from L …

A direct chemical method for the estimation of absolute amounts of synthetic melanin is
established by the use of sodium borohydride, a mild reducing agent for the ketonic or …

A method has been established for the characterization of synthetic melanins obtained from
dopamine, norepinephrine, and structurally related compounds which permits the …

Recent investigations and discussions have emphasized not whether tyrosine was a
precursor in melanin formation as had been the controversy for over fifty years (Fitzpatrick …

In mammals, melanin is synthesized in specialized unicellular secretory glands, known as
melanocytes. Tyrosinase*[EC 1.10. 3.1, o-diphenol: 02 oxidoreductase] catalyzes the …

Natural melanins are composed of two distinct portions; a protein fraction and a
chromophoric backbone. There is no unequivocal evidence for covalent bonding between …