3 for 3: Sequential α‐ketoacid–hydroxylamine (KAHA) ligations with 5‐oxaproline allow
access to the modifier protein UFM1 (Ubiquitin‐fold modifier 1) with a C‐terminal amide …

Targeted protein degradation relies on small molecules that induce new protein–protein
interactions between targets and the cellular protein degradation machinery. Most of these …

Post-translational modification of proteins with ubiquitin (Ub) and Ub chains controls protein
breakdown by the proteasome, cellular localization of proteins, transcriptional activity, and …

The elucidation of emerging biological functions of heterotypic and branched ubiquitin (Ub)
chains requires new strategies for their preparation with defined lengths and connectivity …

Pharmacological control of the ubiquitin-proteasome system (UPS) is of intense interest in
drug discovery. Here, we report the development of chemical inhibitors of the ubiquitin …

Ubiquitin-conjugating enzyme E2 T (UBE2T) plays important roles in ubiquitination of
proteins through participation in transferring ubiquitin to its substrate. Due to its importance …

A hydroxyethylene isostere of the tripeptide Arg-Gly-Leu, representing an important fragment
of a novel cyclic-peptide-based uPA inhibitor, was synthesized in few steps employing as …

Ubiquitin-activating enzyme is the archetype for a family of enzymes catalyzing the ATP-
coupled activation of ubiquitin and other class 1 ubiquitin-like proteins required for their …

Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin
chain architectures guide the binding events and itineraries of modified substrates. Various …

Abstract Ubiquitin-conjugating enzymes (E2) enable protein ubiquitination by conjugating
ubiquitin to their catalytic cysteine for subsequent transfer to a target lysine side chain …