Highlights•mRNA vaccines address many of the weaknesses of conventional vaccine
types.•Innovations in recent years revolutionized the applicability of mRNA vaccines.•mRNA …

Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …

The first proof-of-concept studies about the feasibility of genetic vaccines were published
over three decades ago, opening the way for future development. The idea of nonviral …

Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

Highlights•mRNA vaccines continue to show promise as prophylactic and therapeutic
vaccines.•Clinical data with mRNA cancer vaccines indicate they are tolerated and …

In the last two decades, there has been growing interest in mRNA-based technology for the
development of prophylactic vaccines against infectious diseases. Technological …

Increases in the world's population and population density promote the spread of emerging
pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional …

During the last two decades, there has been broad interest in RNA-based technologies for
the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have …

mRNA vaccines have evolved as promising cancer therapies. These vaccines can encode
tumor-allied antigens, thus enabling personalized treatment approaches. They can also …

Abstract mRNA vaccines have emerged as promising alternative platforms to conventional
vaccines. Their ease of production, low cost, safety profile and high potency render them …