Bim (Bcl-2-interacting mediator of cell death) is a member of the BH3 domain-only subgroup
of Bcl-2 family members, for which three splice variants have been described. Bim is …

Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only
members activate the essential effectors Bax and Bak remains controversial. The indirect …

Proapoptotic Bcl-2 family members activate cell death by neutralizing their anti-apoptotic
relatives, which in turn maintain cell viability by regulating the activation of the cell death …

Bim (Bcl-2-interacting mediator of cell death) is a BH3-only protein (BOP), a pro-apoptotic
member of the Bcl-2 protein family. The Bim mRNA undergoes alternate splicing to give rise …

Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer
membrane permeabilization (MOMP). Members of a subgroup of the Bcl-2 family, known as …

Bim, the Bcl-2 interacting mediator of cell death, is a member of the BH3-only family of pro-
apoptotic proteins. Recent studies have demonstrated that the apoptotic activity of Bim can …

Abstract BH3 (Bcl-2 homology 3)-only proteins of the Bcl-2 family play an essentialrole in
apoptosis. In this study, a novel human BH3-only protein, Bcl-2-interacting mediator (Bim) γ …

Certain members of the Bcl‐2 family inhibit apoptosis while others facilitate this
physiological process of cell death. An expression screen for proteins that bind to Bcl‐2 …

The Bcl-2 homology (BH) 3-only pro-apoptotic Bcl-2 family protein Bim plays an essential
role in the mitochondrial pathway of apoptosis through activation of the BH1–3 multidomain …

Members of the Bcl-2 protein family that share only the Bcl-2 homology 3 (BH3) domain are
known mostly as sentinels for apoptotic stimuli and initiators of apoptosis. One BH3-only …