Intrinsic Capacity and Its Biological Basis: A Scoping Review

MB Beyene, R Visvanathan, AT Amare - The Journal of Frailty & Aging, 2024 - Springer
Background In 2015, the World Health Organization (WHO) introduced the concept of
intrinsic capacity (IC) to define healthy aging based on functional capacity. In this scoping …

Biological features of the outcome-based intrinsic capacity composite scores from a population-based cohort study: pas de deux of biological and functional aging

LC Meng, ST Huang, LN Peng, LK Chen… - Frontiers in …, 2022 - frontiersin.org
Introduction This study aims to develop and validate an integrative intrinsic capacity (IC)
scoring system, to investigate its associations with a wide spectrum of biomarkers and to …

[HTML][HTML] Development and validation of an intrinsic capacity score in the UK Biobank study

MB Beyene, R Visvanathan, M Ahmed, B Benyamin… - Maturitas, 2024 - Elsevier
Abstract Background In 2015, the World Health Organization introduced the concept of
intrinsic capacity (IC) to define the individual-level characteristics that enable an older …

Reference centiles for intrinsic capacity throughout adulthood and their association with clinical outcomes: a cross-sectional analysis from the INSPIRE-T cohort

WH Lu, Y Rolland, S Guyonnet, P de Souto Barreto… - Nature Aging, 2023 - nature.com
Intrinsic capacity (IC), a function-centered construct, is defined as the composite of all
physical and mental capacities of an individual. IC and surrounding environmental factors …

[HTML][HTML] Trajectories of intrinsic capacity: determinants and associations with disability

R Yu, D Lai, G Leung, J Woo - The Journal of nutrition, health and aging, 2023 - Elsevier
Objectives Intrinsic capacity (IC) declines progressively with age, thereby increasing the risk
of disability. However, it is less known whether IC trajectories are associated with disability …

Factors associated with the intrinsic capacity in older adults: A scoping review

X Wei, Y Chen, J Qin, Y Yang, T Yang… - Journal of Clinical …, 2024 - Wiley Online Library
Introduction In 2015, the term 'intrinsic capacity'(IC) was proposed by the World Health
Organisation to promote healthy aging. However, the factors associated with IC are still …

[HTML][HTML] Intrinsic capacity differs from functional ability in predicting 10-year mortality and biological features in healthy aging: results from the I-Lan longitudinal aging …

WJ Lee, LN Peng, MH Lin, CH Loh, FY Hsiao… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
This study aimed to explore the biological features and mortality risk of intrinsic capacity (IC)
and functional ability (FA). Based on data from 1839 participants from the I-Lan Longitudinal …

Defining and assessing intrinsic capacity in older people: a systematic review and a proposed scoring system

S Lopez-Ortiz, S Lista, S Penin-Grandes… - Ageing Research …, 2022 - Elsevier
Abstract Introduction The World Health Organization has introduced the term 'intrinsic
capacity'(IC) as a marker of healthy ageing. However, controversy exists on the definition …

[HTML][HTML] Intrinsic capacity in older adults: recent advances

Y Zhou, L Ma - Aging and disease, 2022 - ncbi.nlm.nih.gov
The global increase in the aging population is expected to result in a shift from disease-
centered to function-centered approaches in response to intensive aging. Thus, the World …

Disentangling the relationship between frailty and intrinsic capacity in healthy community-dwelling older adults: a cluster analysis

J Chew, JP Lim, S Yew, A Yeo, NH Ismail… - The journal of nutrition …, 2021 - Springer
Background Frailty and intrinsic capacity (IC) are distinct but interrelated constructs.
Uncertainty remains regarding how they are related and interact to influence health …