Hypoxic induction of erythropoietin (Epo) and other oxygen-dependent genes is mediated
by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transactivator consisting of an α …

The heterodimeric hypoxia-inducible transcription factor HIF-1 is involved in the oxygen-
regulated transcription of several genes including erythropoietin. Cloning and sequencing of …

Abstract Hypoxia-inducible factor (HIF), an αβ dimer, is the master regulator of oxygen
homeostasis with hundreds of hypoxia-inducible target genes. Three HIF isoforms differing …

Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin
(Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatment …

Activation of the hypoxia‐inducible factor α‐subunits, HIF‐1α and HIF‐2α, seems to be
subject to similar regulatory mechanisms, and transgene approaches suggested partial …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription
factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) …

Hypoxia-inducible factor 1 (HIF-1) binds to cis-acting hypoxia-response elements within the
erythropoietin, vascular endothelial growth factor, and other genes to activate transcription in …

Erythropoietin (Epo) is a glycoprotein hormone that is the primary regulator of red blood cell
production. Epo production increases in response to tissue hypoxia. This increase occurs …

Hypoxia-inducible factor-1α (HIF-1α), a member of the transcription family characterized by a
basic helix-loop-helix (bHLH) domain and a PAS domain, regulates the transcription of …

SUMMARY 1 The mechanisms controlling the expression of the gene encoding for the
hormone erythropoietin (EPO) are exemplary for oxygen‐regulated gene expression. In …