[HTML][HTML] p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
DE Richard, E Berra, E Gothié, D Roux… - Journal of Biological …, 1999 - ASBMB
Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as
vascular endothelial growth factor and erythropoietin in low oxygen conditions. However, the …
vascular endothelial growth factor and erythropoietin in low oxygen conditions. However, the …
Hypoxia rapidly activates HIF‐3α mRNA expression
M Heidbreder, F Fröhlich, O Jöhren… - The FASEB …, 2003 - Wiley Online Library
The role of the hypoxia‐inducible factor (HIF) subunits 1α and 1β in cellular response to
hypoxia is well established, whereas little is known about HIF‐2α and HIF‐3α with respect to …
hypoxia is well established, whereas little is known about HIF‐2α and HIF‐3α with respect to …
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site
I Kvietikova, RH Wenger, HH Marti… - Nucleic Acids …, 1995 - academic.oup.com
Abstract The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity
that specifically recognizes an 8 bp motif known to be essential for hypoxia-inducible …
that specifically recognizes an 8 bp motif known to be essential for hypoxia-inducible …
Activation of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor
PJ Kallio, I Pongratz, K Gradin… - Proceedings of the …, 1997 - National Acad Sciences
In response to hypoxia the hypoxia-inducible factor-1 (HIF-1) mediates transcriptional
activation of a network of genes encoding erythropoietin, vascular endothelial growth factor …
activation of a network of genes encoding erythropoietin, vascular endothelial growth factor …
[HTML][HTML] Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible …
GL Semenza, BH Jiang, SW Leung… - Journal of Biological …, 1996 - ASBMB
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is
expressed when mammalian cells are subjected to hypoxia and which activates …
expressed when mammalian cells are subjected to hypoxia and which activates …
[HTML][HTML] Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP …
Hypoxia‐inducible factor 1 α (HIF1α) and its related factor, HLF, activate expression of a
group of genes such as erythropoietin in response to low oxygen. Transfection analysis …
group of genes such as erythropoietin in response to low oxygen. Transfection analysis …
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
GL Wang, B Jiang, EA Rue… - Proceedings of the …, 1995 - National Acad Sciences
Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2
tension and is necessary for transcriptional activation mediated by the erythropoietin gene …
tension and is necessary for transcriptional activation mediated by the erythropoietin gene …
Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression
Hypoxia-inducible factors (HIFs) locate to HIF-binding sites (HBSs) within the hypoxia-
response elements (HREs) of oxygen-regulated genes. Whereas HIF-1α is expressed …
response elements (HREs) of oxygen-regulated genes. Whereas HIF-1α is expressed …
The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
C Warnecke, A Weidemann, M Volke, R Schietke… - Experimental cell …, 2008 - Elsevier
Cellular integrity in hypoxia is dependent on molecular adaptations dominated by the
heterodimeric transcription factor hypoxia-inducible factor (HIF). The HIF complex contains …
heterodimeric transcription factor hypoxia-inducible factor (HIF). The HIF complex contains …
Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1
T Hellwig-Bürgel, K Rutkowski… - Blood, The Journal …, 1999 - ashpublications.org
The rate of transcription of several genes encoding proteins involved in O2 and energy
homeostasis is controlled by hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA …
homeostasis is controlled by hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA …