Background Adoptive T-cell based immunotherapies constitute a promising approach to
treat cancer, however, a major problem is to obtain effective and long-lasting anti-tumor …

The CX3C chemokine fractalkine (CX3CL1) exists as both a membrane‐bound form
promoting firm cell‐cell adhesion and a soluble form chemoattracting leukocytes expressing …

Abstract Fractalkine (CX3CL1) is a unique membrane‐bound CX3C chemokine that serves
as a potent chemoattractant for lymphocytes. The hypothesis of this study is that dendritic …

Fractalkine (FKN) is a unique CX3C chemokine (CX3CL1) known to induce both adhesion
and migration of leukocytes mediated by a membrane-bound and a soluble form …

Abstract CX3CL1/Fractalkine (FK), a chemokine existing in both secreted and membrane
anchored form, was reported to induce suppressive activities in tumor models. Here, we …

Due to their chemoattractant properties stimulating the accumulation of infiltrating immune
cells in tumors, chemokines are known to have antitumor effects. Fractalkine, a unique …

CX3CR1 has been described previously as a marker of human cytotoxic effector cells. We
evaluated the possibility of using its ligand, CX3CL1, to redirect immune response against …

Human colorectal cancer (CRC) is a frequent neoplasia in Western countries, and its
metastatic progression is a major cause of cancer-related death. In search of specific …

Innate immunity is critically important for tumor surveillance and regulating tumor metastasis.
Fractalkine (FKN, CX3CL1), operating through the receptor CX3CR1, is an effective …

Transendothelial migration (TEM) of tumor cells is a crucial step in metastasis formation. The
prevailing paradigm is that the mechanism underlying TEM of tumor cells is similar to that of …