Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of
membranes, but it is unclear which biological processes are influenced by their regulation …

The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to
an inability to selectively manipulate membrane composition in vivo. Here we show that the …

Phospholipids are important determinants of membrane biophysical properties, but the
impact of membrane acyl chain composition on dietary-lipid absorption is unknown. Here we …

Phospholipids are major constituents of biological membranes. The fatty acyl chain
composition of phospholipids determines the biophysical properties of membranes and …

Background & Aims Phosphatidylcholines (PCs) are structural and functional constituents of
cell membranes. The activity of acyltransferase (lysophosphatidylcholine acyltransferase …

Background Lipids are stored within cells in lipid droplets (LDs). They consist of a core of
neutral lipids surrounded by a monolayer of phospholipids, predominantly …

Phosphatidylcholine (PC) is synthesized through the Kennedy pathway, but more than 50%
of PC is remodeled through the Lands cycle, ie the deacylation and reacylation of PC to …

PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding
their precise roles and modes of action remains challenging. PUFAs are precursors for a …

Animal cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein
(LDL), which releases cholesterol in lysosomes. The cholesterol moves to the endoplasmic …

Fatty liver disease (FLD) is a burgeoning health problem. A missense variant (I148M) in
patatin-like phospholipase domain–containing protein 3 (PNPLA3) confers susceptibility to …