The Timing oflin-4RNA Accumulation Controls the Timing of Postembryonic Developmental Events inCaenorhabditis elegans
R Feinbaum, V Ambros - Developmental biology, 1999 - Elsevier
Thelin-4gene encodes a small RNA that is required to translationally represslin-14toward
the end of the first larval stage ofCaenorhabditis elegansdevelopment. To determine if the …
the end of the first larval stage ofCaenorhabditis elegansdevelopment. To determine if the …
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
PH Olsen, V Ambros - Developmental biology, 1999 - Elsevier
lin-4 encodes a small RNA that is complementary to sequences in the 3′ untranslated
region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of …
region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of …
Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
K Seggerson, L Tang, EG Moss - Developmental biology, 2002 - Elsevier
The heterochronic gene lin-28 of the nematode Caenorhabditis elegans controls the relative
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …
Structure and Function Analysis of LIN-14, a Temporal Regulator of Postembryonic Developmental Events in Caenorhabditis elegans
Y Hong, RC Lee, V Ambros - Molecular and cellular biology, 2000 - Taylor & Francis
During postembryonic development of Caenorhabditis elegans, the heterochronic gene lin-
14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 …
14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 …
Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin‐28 in Caenorhabditis elegans
K Morita, M Han - The EMBO Journal, 2006 - embopress.org
The timing of postembryonic developmental programs in Caenorhabditis elegans is
regulated by a set of so‐called heterochronic genes, including lin‐28 that specifies second …
regulated by a set of so‐called heterochronic genes, including lin‐28 that specifies second …
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
RC Lee, RL Feinbaum, V Ambros - cell, 1993 - cell.com
Summary h-4 is essential for the normal temporal control of diverse postembryonic
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14 …
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14 …
A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.
I Ha, B Wightman, G Ruvkun - Genes & development, 1996 - genesdev.cshlp.org
The Caenorhabditis elegans heterochronic gene lin-14 generates a temporal gradient of the
LIN-14 proteins to control stage-specific patterns of cell lineage during development. Down …
LIN-14 proteins to control stage-specific patterns of cell lineage during development. Down …
Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations …
The heterochronic gene lin-14 controls the temporal sequence of developmental events in
the C. elegans postembryonic cell lineage. It encodes a nuclear protein that is normally …
the C. elegans postembryonic cell lineage. It encodes a nuclear protein that is normally …
The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans
AE Rougvie, V Ambros - Development, 1995 - journals.biologists.com
ABSTRACT A hierarchy of heterochronic genes, lin-4, lin-14, lin-28 and lin-29, temporally
restricts terminal differentiation of Caenorhabditis elegans hypodermal seam cells to the …
restricts terminal differentiation of Caenorhabditis elegans hypodermal seam cells to the …
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
The C. elegans heterochronic gene pathway consists of a cascade of regulatory genes that
are temporally controlled to specify the timing of developmental events. Mutations in …
are temporally controlled to specify the timing of developmental events. Mutations in …
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