Among the deadliest type of cancers, lung cancer faces several challenges in diagnosis and
treatment: late diagnosis and misdiagnosis, inadequate tumor sampling, and resistance …

Small cell lung cancer (SCLC) is often a heterogeneous tumor, where dynamic regulation of
key transcription factors can drive multiple populations of phenotypically different cells which …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …

Single-cell sequencing, which is used to detect clinically important tumor subpopulations, is
necessary for understanding tumor heterogeneity. Here, we analyzed transcriptomic data …

Cancer interception refers to actively blocking the cancer development process by
preventing progression of premalignancy to invasive disease. The rate-limiting steps for …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Intratumoral heterogeneity in non–small cell lung cancer (NSCLC) has been appreciated at
the histological and cellular levels, but the association of less differentiated pathology with …

Over the past several years, we have witnessed a resurgence of interest in the biology and
therapeutic vulnerabilities of small-cell lung cancer (SCLC). This has been driven in part …

Advanced metastatic cancer poses utmost clinical challenges and may present molecular
and cellular features distinct from an early-stage cancer. Herein, we present single-cell …

Small-cell lung cancer (SCLC) is the most fatal form of lung cancer. Intratumoral
heterogeneity, marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell …