Although the knowledge accumulated on the transcriptional regulations of eukaryotes is
significant, the knowledge on their translational regulations remains limited. Thus, we …

In the early 1980s, it was recognized that the equimolar accumulation of ribosomal proteins
(r-proteins) in eukaryotes is maintained by coordinated regulation at various levels of gene …

TOP mRNAs are vertebrate transcripts which contain a 5′ terminal oligopyrimidine tract
(5′ TOP), encode for ribosomal proteins and elongation factors 1α and 2, and are …

Upon cell-cycle arrest or nutrient deprivation, the cellular rate of ribosome production is
reduced significantly. In mammalian cells, this effect is achieved in part through a co …

Cells encountering hostile growth conditions, like those residing in the middle of a newly
developing solid tumor, conserve resources and energy by downregulating protein …

Various mitogenic or growth inhibitory stimuli induce a rapid change in the association of
terminal oligopyrimidine (TOP) mRNAs with polysomes. It is generally believed that such …

To understand the mechanism of transcriptional regulation, it is essential to identify and
characterize the promoter, which is located proximal to the mRNA start site. To identify the …

The synthesis of many mammalian proteins associated with the translational apparatus is
selectively regulated by mitogenic and nutritional stimuli, at the translational level. The …

Background Experimental investigation of transcription is still a very labor-and time-
consuming process. Only a few transcription initiation scenarios have been studied in detail …

TOP mRNAs encode components of the translational apparatus, and repression of their
translation comprises one mechanism, by which cells encountering amino acid deprivation …