A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF
A Watari, Y Li, S Higashiyama, M Yutsudo - Experimental Cell Research, 2012 - Elsevier
The protein p14ARF is a known tumor suppressor protein controlling cell proliferation and
survival, which mainly localizes in nucleoli. However, the regulatory mechanisms that …
survival, which mainly localizes in nucleoli. However, the regulatory mechanisms that …
Regulation of p14ARF through subnuclear compartmentalization
RA Gjerset, K Bandyopadhyay - Cell Cycle, 2006 - Taylor & Francis
The p53-mediated pathway cell cycle arrest and apoptosis is central to cancer and an
important point of focus for therapeutics development. The p14ARF (" ARF") tumor …
important point of focus for therapeutics development. The p14ARF (" ARF") tumor …
p14ARF Prevents Proliferation of Aneuploid Cells by Inducing p53‐Dependent Apoptosis
Weakening the Spindle Assembly Checkpoint by reduced expression of its components
induces chromosome instability and aneuploidy that are hallmarks of cancer cells. The …
induces chromosome instability and aneuploidy that are hallmarks of cancer cells. The …
P14ARF: The Absence that Makes the Difference
D Cilluffo, V Barra, A Di Leonardo - Genes, 2020 - mdpi.com
P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated
in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle …
in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle …
Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis
Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …
p53-independent apoptosis is induced by the p19ARF tumor suppressor
K Tsuji, K Mizumoto, H Sudo, K Kouyama… - Biochemical and …, 2002 - Elsevier
p19ARF is a potent tumor suppressor. By inactivating Mdm2, p19ARF upregulates p53
activities to induce cell cycle arrest and sensitize cells to apoptosis in the presence of …
activities to induce cell cycle arrest and sensitize cells to apoptosis in the presence of …
Recombinant adenovirus-mediated p14ARF overexpression sensitizes human breast cancer cells to cisplatin
X Deng, M Kim, D Vandier, Y Jung, T Rikiyama… - Biochemical and …, 2002 - Elsevier
p14ARF, the alternative product from the human INK4a/ARF locus, is one of the major
targets for alterations in the development of human cancers. Overexpression of p14ARF …
targets for alterations in the development of human cancers. Overexpression of p14ARF …
Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFκB
G Yang, F Yu, H Fu, F Lu, B Huang, L Bai… - Molecular and cellular …, 2007 - Springer
Abstract APR3 (apoptosis related protein 3) is a novel gene highly conserved across
species. Analysis of the data about APR3 available at GEO profiles revealed consistent and …
species. Analysis of the data about APR3 available at GEO profiles revealed consistent and …
Low p14ARF expression in neuroblastoma cells is associated with repressed histone mark status, and enforced expression induces growth arrest and apoptosis
D Dreidax, S Gogolin, C Schroeder… - Human molecular …, 2013 - academic.oup.com
The TP53 tumor suppressor pathway is abrogated by TP53 mutations in the majority of
human cancers. Increased levels of wild-type TP53 in aggressive neuroblastomas appear …
human cancers. Increased levels of wild-type TP53 in aggressive neuroblastomas appear …
P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner
XW Yuan, XF Zhu, XF Huang, PY Sheng… - Cancer Biology & …, 2007 - Taylor & Francis
The tumor suppressor p14ARF, encoded by the INK4a/ARF locus, is often disrupted in
human cancers. p14ARF triggers cell cycle arrest and sensitizes cells to apoptosis in the …
human cancers. p14ARF triggers cell cycle arrest and sensitizes cells to apoptosis in the …