Oxidative stress is important in pathogenesis of liver fibrosis, which is the result of deposition
of excessive ECM proteins produced by activated hepatic stellate cells (HSCs). Reducing …

Abstract Background and Aim Liver fibrosis is associated with the deposition of the
extracellular matrix, and hepatic stellate cells (HSC s) are the major source of these matrix …

Abstract The phytoalexin Resveratrol (3, 5, 4′-trihydroxystilbene; RSV) has been related to
numerous beneficial effects on health by its cytoprotection and chemoprevention activities …

Previously, we demonstrated that Rhizoma Paridis saponins (RPS), the major active
component of Rhizoma Paridis, may exhibit hepatoprotective effects. The present study …

Abstract Background and Aim: There is currently no safe and effective treatment for liver
fibrosis. We have previously shown that Stephania tetrandra (ST) and Salvia miltiorrhiza …

In this study, the protective effect of extract of Hsian-tsao (Mesona procumbens)(EHT)
against liver fibrogenesis in carbon tetrachloride (CCl4)-injured rats was evaluated. The …

BACKGROUND Fasudil, as a Ras homology family member A (RhoA) kinase inhibitor, is
used to improve brain microcirculation and promote nerve regeneration clinically. Increasing …

Background: The current treatments of liver diseases are not sufficiently effective, and there
has been no therapy that can successfully prevent liver failure and its complications …

Background In the development of liver fibrosis, activated hepatic stellate cells (HSCs)
contribute to the synthesis and deposition of extracellular matrix (ECM) proteins. HSC …

Liver diseases such as hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma are one of
the major health challenges in the world and many conditions such as inadequate nutrition …