Stem-cell-derived human microglia transplanted into mouse brain to study human disease
N Fattorelli, A Martinez-Muriana, L Wolfs, I Geric… - Nature protocols, 2021 - nature.com
Microglia are critically involved in complex neurological disorders with a strong genetic
component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia …
component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia …
Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration
AM Speicher, H Wiendl, SG Meuth… - Molecular …, 2019 - Springer
Microglia play an essential role for central nervous system (CNS) development and
homeostasis and have been implicated in the onset, progression, and clearance of …
homeostasis and have been implicated in the onset, progression, and clearance of …
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain
DS Svoboda, MI Barrasa, J Shu… - Proceedings of the …, 2019 - National Acad Sciences
Microglia are essential for maintenance of normal brain function, with dysregulation
contributing to numerous neurological diseases. Protocols have been developed to derive …
contributing to numerous neurological diseases. Protocols have been developed to derive …
Efficient derivation of microglia-like cells from human pluripotent stem cells
Microglia, the only lifelong resident immune cells of the central nervous system (CNS), are
highly specialized macrophages that have been recognized to have a crucial role in …
highly specialized macrophages that have been recognized to have a crucial role in …
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells
H Pandya, MJ Shen, DM Ichikawa, AB Sedlock… - Nature …, 2017 - nature.com
Microglia are resident inflammatory cells of the CNS and have important roles in
development, homeostasis and a variety of neurologic and psychiatric diseases. Difficulties …
development, homeostasis and a variety of neurologic and psychiatric diseases. Difficulties …
Development and validation of a simplified method to generate human microglia from pluripotent stem cells
Background Microglia, the principle immune cells of the brain, play important roles in
neuronal development, homeostatic function and neurodegenerative disease. Recent …
neuronal development, homeostatic function and neurodegenerative disease. Recent …
Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia
SJ Washer, M Perez-Alcantara, Y Chen, J Steer… - Scientific Reports, 2022 - nature.com
There is increasing genetic evidence for the role of microglia in neurodegenerative
diseases, including Alzheimer's, Parkinson's, and motor neuron disease. Therefore, there is …
diseases, including Alzheimer's, Parkinson's, and motor neuron disease. Therefore, there is …
Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
Microglia, the brain-resident macrophages, exhibit highly dynamic functions in
neurodevelopment and neurodegeneration. Human microglia possess unique features as …
neurodevelopment and neurodegeneration. Human microglia possess unique features as …
A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response
Microglia are increasingly implicated in brain pathology, particularly neurodegenerative
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
Concise review: modeling neurodegenerative diseases with human pluripotent stem cell-derived microglia
W Haenseler, L Rajendran - Stem Cells, 2019 - academic.oup.com
Inflammation of the brain and the consequential immunological responses play pivotal roles
in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease …
in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease …