Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction

CE Brightling - Pulmonary pharmacology & therapeutics, 2011 - Elsevier
Eosinophilic airway inflammation is commonly observed in chronic cough in patients with
asthma and non-asthmatic eosinophilic bronchitis. Indeed asthma and non-asthmatic …

Cough due to asthma and nonasthmatic eosinophilic bronchitis

CE Brightling - Lung, 2010 - Springer
Asthma and nonasthmatic eosinophilic bronchitis are among the most common causes of
chronic cough, accounting for about 25 and 10% of cases, respectively. Chronic cough due …

A role for eosinophils in airway remodelling in asthma

AB Kay, S Phipps, DS Robinson - Trends in immunology, 2004 - cell.com
Over the years, the role of the eosinophil in asthma and allergic processes has been
disputed. Recent human experiments using a humanised monoclonal antibody to interleukin …

Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease

L George, CE Brightling - Therapeutic advances in chronic …, 2016 - journals.sagepub.com
The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are
common affecting over 500 million people worldwide and causing substantial morbidity and …

Pathogenesis of airway inflammation in bronchial asthma

K Nakagome, M Nagata - Auris Nasus Larynx, 2011 - Elsevier
Bronchial asthma is a chronic disorder characterized by airway inflammation, reversible
airway obstruction, and airway hyperresponsiveness. Eosinophils are believed to play …

The eosinophil and airway remodelling in asthma

P Venge - The clinical respiratory journal, 2010 - Wiley Online Library
Objectives: Eosinophils are common findings cells in allergic asthma as is sub‐base
membrane thickening of the airways. The objective of this review was to summarise some …

Cough in asthma is due to eosinophilic airway inflammation: a pro/con debate

A Niimi, CE Brightling, PV Dicpinigaitis - Lung, 2014 - Springer
Multiple prospective studies have demonstrated that asthma is among the most common
etiologies of chronic cough, along with upper-airway cough syndrome (formerly known as …

Eosinophils and tissue remodeling: relevance to airway disease

S Siddiqui, C Bachert, L Bjermer, KM Buchheit… - Journal of Allergy and …, 2023 - Elsevier
The ability of human tissue to reorganize and restore its existing structure underlies tissue
homeostasis in the healthy airways, but in disease can persist without normal resolution …

IL‐5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation

A Trifilieff, Y Fujitani, AJ Coyle, M Kopf… - Clinical & …, 2001 - Wiley Online Library
Background and objectives Lung remodelling is a recognized feature of chronic asthma. In
the present study, we have used IL‐5‐deficient mice to evaluate the role of this cytokine and …

Airway remodeling contributes to the progressive loss of lung function in asthma: an overview

RM Pascual, SP Peters - Journal of Allergy and Clinical Immunology, 2005 - Elsevier
Airway inflammation, airflow obstruction, and bronchial hyperresponsiveness are
characteristic phenotypic features of asthma. Clinically, airflow obstruction in asthma often is …