Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

Despite serving a crucial purpose in neurobiological function, transition metals play a
sinister part in the aging brain, where the abnormal accumulation and distribution of reactive …

This chapter reviews transition metal ion dysregulation and oxidative stress in the
pathogenesis of Alzheimer's disease. It focuses on the roles of metal ions in …

Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …

Copper is essential for some of the enzymes that have a role in brain metabolism.
Sophisticated mechanisms balance copper import and export to ensure proper nutrient …

Alzheimer's disease (AD) has become linked to inflammation and metal biology. Metals
(copper, zinc and iron) and inflammatory cytokines are significant factors that increase the …

Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …

Redox chemistry arising from transition metals copper and iron are the principal chemical
origin of the radicals and reactive oxygen species that are implicated in the pathogenesis of …

The postmortem Alzheimer's disease brain is characterized histochemically by the presence
of extracellular amyloid plaques and neurofibrillary tangles. Also consistent with the disease …

Alzheimer's disease (AD) is the most common form of adult neurode-generation and is
characterised by progressive loss of cognitive function leading to death. The …