[PDF][PDF] Interleukin‐22 treatment ameliorates alcoholic liver injury in a murine model of chronic‐binge ethanol feeding: role of signal transducer and activator of …

SH Ki, O Park, M Zheng, O Morales‐Ibanez… - …, 2010 - Wiley Online Library
Abstract Interleukin‐22 (IL‐22), a recently identified member of the IL‐10 family of cytokines
that is produced by Th17 and natural killer cells, plays an important role in controlling …

Hepatoprotective and anti‐inflammatory cytokines in alcoholic liver disease

B Gao - Journal of gastroenterology and hepatology, 2012 - Wiley Online Library
The activation of innate immunity by various factors (eg lipopolysaccharide and
complements) plays an important role in initiating and promoting alcoholic liver injury via the …

Hepatoprotective and anti‐fibrotic functions of interleukin‐22: therapeutic potential for the treatment of alcoholic liver disease

X Kong, D Feng, S Mathews… - … of Gastroenterology and …, 2013 - Wiley Online Library
Abstract Interleukin‐22 (IL‐22) plays a key role in promoting antimicrobial immunity and
tissue repair at barrier surfaces by binding to the receptors IL‐22 R 1, which is generally …

[PDF][PDF] Inflammation‐associated interleukin‐6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in …

AM Miller, H Wang, A Bertola, O Park, N Horiguchi… - …, 2011 - Wiley Online Library
Alcoholic and nonalcoholic steatohepatitis are characterized by fatty liver plus inflammation.
It is generally believed that steatosis promotes inflammation, whereas inflammation in turn …

[PDF][PDF] IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability …

O El-Assal, F Hong, WH Kim, S Radaeva, B Gao - Cell Mol Immunol, 2004 - Citeseer
One of the most common liver disorders worldwide, alcohol-induced liver injury is the direct
consequence of alcohol-induced hepatotoxicity and cross-interactions between alcohol …

A role for interleukin‐10 in alcohol‐induced liver sensitization to bacterial lipopolysaccharide

DB Hill, NB D'Souza, EY Lee… - Alcoholism: Clinical …, 2002 - Wiley Online Library
Background: Proinflammatory cytokines play an important role in alcohol‐induced liver
injury. The role of anti‐inflammatory cytokines in the initiation and progression of alcoholic …

An open‐label, dose‐escalation study to assess the safety and efficacy of IL‐22 agonist F‐652 in patients with alcohol‐associated hepatitis

JP Arab, TS Sehrawat, DA Simonetto, VK Verma… - …, 2020 - Wiley Online Library
Background and Aims Interleukin‐22 has beneficial effects on inflammation and impaired
hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a …

The effect of inflammatory cytokines in alcoholic liver disease

H Kawaratani, T Tsujimoto, A Douhara… - Mediators of …, 2013 - Wiley Online Library
Alcohol is the most common cause of liver disease in the world. Chronic alcohol
consumption leads to hepatocellular injury and liver inflammation. Inflammatory cytokines …

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

T Hendrikx, YI Duan, Y Wang, JH Oh, LM Alexander… - Gut, 2019 - gut.bmj.com
Objective Antimicrobial C-type lectin regenerating islet-derived 3 gamma (REG3G) is
suppressed in the small intestine during chronic ethanol feeding. Our aim was to determine …

Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury

JL Rendon, X Li, S Akhtar, MA Choudhry - Shock, 2013 - journals.lww.com
Abstract Interleukin-22 (IL-22) maintains gut epithelial integrity and expression of
antimicrobial peptides Reg3β and Reg3γ. Our laboratory has shown that acute …