The responsiveness to noxious thermal, mechanical, and chemical stimuli was examined in
adult rats that had been treated neonatally with capsaicin. A range of capsaicin doses was …

Acute capsaicin treatment in adult rats has been shown to increase firing rates in peripheral
sensory nerves involved in the transmission of nociceptive input due to chemical irritants or …

Substance P (SP) is present in unmyelinated primary afferent fibres entering the spinal cord
(Hokfelt et al 1975) and has been suggested to be involved in pain transmission in the …

Data obtained from neonatally treated rats are fairly consistent. However, there is
disagreement as to whether mechanical and thermal nociceptive thresholds are elevated or …

The nociceptive threshold as determined by the reaction time in the hot-plate and tail-flick
tests was measured 3 to 4 months after pretreatment of young rats with capsaicin (50 mg kg …

Thermal and mechanical nociceptive thresholds and somato-visceral reflexes have been
studied in normal rats and in rats treated neonatally with capsaicin. Mechanical nociceptive …

Over the past several decades capsaicin, a natural product of certain species of red pepper,
has been found to have a broad range of physiological effects in adult animals. Recent …

Capsaicin, 8-methyl-N-vanillyl-6-nonenamide, is the pungent algesic substance of the red
pepper. On local or systemic injection capsaicin causes a marked stimulation of peripheral …

Systemic capsaicin treatment of neonatal and adult rats is known to affect unmyelinated
afferents. However, the systemic route of administration presents several disadvantages and …

The aim of the present investigation was to determine the acute effects of single doses of
capsaicin, administered either peripherally or centrally, against responses induced by …