The immunoproteasome is predominantly expressed in monocytes and lymphocytes and is
responsible for the generation of antigenic peptides for cell-mediated immunity. Upon the …

The ubiquitin-proteasome system (UPS) is the major non-lysosomal proteolytic system for
the degradation of abnormal or damaged proteins no longer required. The proteasome is …

The immunoproteasome, a specialized form of proteasome, is mainly expressed in
lymphocytes and monocytes of jawed vertebrates and responsible for the generation of …

The proteasome, a large multisubunit protease complex, has been extensively investigated
over the years, greatly enhancing our understanding of critical roles that the proteasome …

The ubiquitin-proteasome system (UPS) plays a vital role in maintaining protein
homeostasis and regulating numerous cellular processes. The proteasome, a multi-protease …

The immunoproteasome is a highly efficient proteolytic machinery derived from the
constitutive proteasome and is abundantly expressed in immune cells. The …

The immunoproteasome, a specialized variant of the constitutive one, is predominantly
expressed in lymphocytes and monocytes of jawed vertebrates and is considered to be …

Remarkable successes with the FDA-approved proteasome inhibitors bortezomib
(Velcade®) and carfilzomib (Kyprolis®) have proved that the proteasome is an effective …

Suppression of proteasome function with the first-in-class small molecule inhibitor
bortezomib is a rational therapeutic strategy against several hematologic malignancies …

The development of immunoproteasome‐selective inhibitors is a promising strategy for
treating hematologic malignancies, autoimmune and inflammatory diseases. In this context …