Inactivating MEN1 mutations are the most common genetic defects present in sporadic and
inherited pancreatic neuroendocrine tumours (PNETs). The lack of interventional therapies …

Pancreatic neuroendocrine tumours (PNETs) might occur as a non-familial isolated
endocrinopathy or as part of a complex hereditary syndrome, such as multiple endocrine …

Pancreatic neuroendocrine tumors (PanNET) are a group of rare sporadic malignant tumors
in the pancreas. MEN1 is the most frequently mutated gene in PanNETs. The MEN1 …

Menin is a tumor suppressor protein mutated in patients with multiple endocrine neoplasia
type 1. We show that menin is essential for canonical Wnt/β-catenin signaling in cultured …

Multiple endocrine neoplasia type 1 (MEN1) is a genetic syndrome in which patients
develop neuroendocrine tumors (NETs), including pancreatic neuroendocrine tumors …

Patients with pancreatic neuroendocrine tumors (PNET) commonly develop advanced
disease and require systemic therapy. However, treatment options remain limited, in part …

Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly
neoplasms. A recent increased understanding of their molecular biology has contributed to …

Pancreatic neuroendocrine tumors (pNETs) are a group of heterogeneous tumors originated
from progenitor cells. As these tumors are predominantly non-functional, most of them …

Context: Sixty to 80% of multiple endocrine neoplasia type 1 (MEN1) patients develop
pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in …

The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To
induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively …