[HTML][HTML] Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours
X Jiang, Y Cao, F Li, Y Su, Y Li, Y Peng… - Nature …, 2014 - nature.com
Inactivating MEN1 mutations are the most common genetic defects present in sporadic and
inherited pancreatic neuroendocrine tumours (PNETs). The lack of interventional therapies …
inherited pancreatic neuroendocrine tumours (PNETs). The lack of interventional therapies …
Current and emerging therapies for PNETs in patients with or without MEN1
M Frost, KE Lines, RV Thakker - Nature Reviews Endocrinology, 2018 - nature.com
Pancreatic neuroendocrine tumours (PNETs) might occur as a non-familial isolated
endocrinopathy or as part of a complex hereditary syndrome, such as multiple endocrine …
endocrinopathy or as part of a complex hereditary syndrome, such as multiple endocrine …
MEN1 Degradation Induced by Neddylation and the CUL4B–DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression
J Xu, Z Ye, Q Zhuo, H Gao, Y Qin, X Lou, W Zhang… - Cancer research, 2023 - AACR
Pancreatic neuroendocrine tumors (PanNET) are a group of rare sporadic malignant tumors
in the pancreas. MEN1 is the most frequently mutated gene in PanNETs. The MEN1 …
in the pancreas. MEN1 is the most frequently mutated gene in PanNETs. The MEN1 …
Menin promotes the Wnt signaling pathway in pancreatic endocrine cells
G Chen, M Wang, S Farley, LY Lee, LC Lee… - Molecular Cancer …, 2008 - AACR
Menin is a tumor suppressor protein mutated in patients with multiple endocrine neoplasia
type 1. We show that menin is essential for canonical Wnt/β-catenin signaling in cultured …
type 1. We show that menin is essential for canonical Wnt/β-catenin signaling in cultured …
[HTML][HTML] Two well-differentiated pancreatic neuroendocrine tumor mouse models
C Wong, LH Tang, C Davidson, E Vosburgh… - Cell Death & …, 2020 - nature.com
Multiple endocrine neoplasia type 1 (MEN1) is a genetic syndrome in which patients
develop neuroendocrine tumors (NETs), including pancreatic neuroendocrine tumors …
develop neuroendocrine tumors (NETs), including pancreatic neuroendocrine tumors …
A patient-derived xenograft model of pancreatic neuroendocrine tumors identifies sapanisertib as a possible new treatment for everolimus-resistant tumors
CE Chamberlain, MS German, K Yang, J Wang… - Molecular cancer …, 2018 - AACR
Patients with pancreatic neuroendocrine tumors (PNET) commonly develop advanced
disease and require systemic therapy. However, treatment options remain limited, in part …
disease and require systemic therapy. However, treatment options remain limited, in part …
Current understanding of the molecular biology of pancreatic neuroendocrine tumors
J Zhang, R Francois, R Iyer, M Seshadri… - Journal of the …, 2013 - academic.oup.com
Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly
neoplasms. A recent increased understanding of their molecular biology has contributed to …
neoplasms. A recent increased understanding of their molecular biology has contributed to …
[HTML][HTML] Molecular biology of pancreatic neuroendocrine tumors: From mechanism to translation
X Shen, X Wang, X Lu, Y Zhao, W Guan - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic neuroendocrine tumors (pNETs) are a group of heterogeneous tumors originated
from progenitor cells. As these tumors are predominantly non-functional, most of them …
from progenitor cells. As these tumors are predominantly non-functional, most of them …
Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain
DK Bartsch, EP Slater, M Albers… - The Journal of …, 2014 - academic.oup.com
Context: Sixty to 80% of multiple endocrine neoplasia type 1 (MEN1) patients develop
pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in …
pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in …
Conditional Deletion of Men1 in the Pancreatic β-Cell Leads to Glucagon-Expressing Tumor Development
F Li, Y Su, Y Cheng, X Jiang, Y Peng, Y Li, J Lu… - …, 2015 - academic.oup.com
The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To
induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively …
induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively …