… In conclusion, half of tumors with acquired resistance to gefitinib had secondary T790M
mutations. No novel mutations in the EGFR gene were present in contrast to CML. …

… of the EGFR gene were examined in both the pre-treatment and the post-treatment gefitinib
resistant tumors in … Neither MET gene amplification nor HGF were observed in their gefitinib-…

… and related genes affect sensitivity to EFGR-TKIs. We also discuss molecular mechanisms
of acquired resistance … created T790M of the EGFR gene results in gefitinib resistance. ( 53 ) …

… in gene expression patterns between gefitinib-resistant (LNCaP, PC3) cells and gefitinib-…
signaling or antitumor activity by gefitinib (17), we arbitrarily selected four PTEN-related …

… , to further discover gefitinib resistance related genes, we report a construction of gefitinib-resistant
cell line and the approach of transcriptome and CNAs analyses on the resistance and …

… to a tyrosine kinase inhibitor (TKI), gefitinib. Despite the dramatic response to this inhibitor, …
dramatic improvement by gefitinib treatment. The DNA sequence of the EGFR gene in a tumor …

… between EGFR and other members of ERBB family may also lead to acquired resistance
to gefitinib, although the genetic mechanisms underlying this phenomenon remain unclear. …

… Insertions in exon 20 and T790M missense mutation, however, are thought to be early genetic
events which confer EGFR-TKI resistance in NSCLCs [5]. It is thought that the threonine-to-…

… genes related to gefitinib acquired resistance in NSCLC were identified by combining WGCNA
and differential gene … that may overcome the acquired resistance to gefitinib in NSCLC. …

… gefitinib resistance, and selection on a background of EGFR genetic heterogeneity also
contributes to acquisition of resistance in a proportion of NSCLCs. © 2008 Wiley-Liss, Inc. …