[HTML][HTML] RBE and related modeling in carbon-ion therapy

CP Karger, P Peschke - Physics in Medicine & Biology, 2017 - iopscience.iop.org
Carbon ion therapy is a promising evolving modality in radiotherapy to treat tumors that
are radioresistant against photon treatments. As carbon ions are more effective in normal and …

[HTML][HTML] Carbon ion therapy: a review of an advanced technology

J Kim, JM Park, HG Wu - Progress in Medical Physics, 2020 - synapse.koreamed.org
carbon ions. HIT studied helium ion beams using measurements and Monte Carlo simulation
Treatment planning for carbon ions is similar to that of protons; the only major difference is …

Comparative risk predictions of second cancers after carbon-ion therapy versus proton therapy

JG Eley, T Friedrich, KL Homann, RM Howell… - International Journal of …, 2016 - Elsevier
… term relating RBE for tumor initiation versus LET for carbon; <… our risk model, and the absorbed
dose within the simple model … our full model indicate that, on average, carbon-ion therapy

Radiobiological issues in prospective carbon ion therapy trials

P Fossati, N Matsufuji, T Kamada, CP Karger - Medical Physics, 2018 - Wiley Online Library
… 200 kV x ray in the original model to that at the center of a carbon ion “reference SOBP.” This
… using a different RBE model to achieve results similar to those reported by another facility? …

[HTML][HTML] Review of the existing relative biological effectiveness models for carbon ion beam therapy

Y Kim, J Kim, S Cho - Progress in Medical Physics, 2020 - synapse.koreamed.org
model for the carbon ion RBE [27]. The MKM is mainly used in Japan for carbon ion
radiotherapy… Here, γ characterizes the beam quality and is related to the variance of the …

A mechanism-based approach to predict the relative biological effectiveness of protons and carbon ions in radiation therapy

MC Frese, KY Victor, RD Stewart, DJ Carlson - International Journal of …, 2012 - Elsevier
… and carbon ion RBE in representative spread-out Bragg peaks is derived using the mechanistic
repair-misrepair-fixation (RMF) modelSimilar trends in α across a SOBP are found in the …

Assessment of RBE-weighted dose models for carbon ion therapy toward modernization of clinical practice at HIT: in vitro, in vivo, and in patients

S Mein, C Klein, B Kopp, G Magro, S Harrabi… - International Journal of …, 2020 - Elsevier
… (RBE) in carbon ion therapy and associated models toward the … dose (D RBE ) modeling
for carbon ions using LEM1 and is it … Which RBE model should current and future heavy ion

[HTML][HTML] Carbon ion radiobiology

W Tinganelli, M Durante - Cancers, 2020 - mdpi.com
… advantages of carbon ions compared to X-rays are similar to … treatment of some cancers
characterized by high mortality. … Pre-clinical studies with C-ions therapy in a swine model gave …

[HTML][HTML] Rectum dose constraints for carbon ion therapy: relative biological effectiveness model dependence in relation to clinical outcomes

K Choi, S Molinelli, S Russo, A Mirandola, MR Fiore… - Cancers, 2019 - mdpi.com
… advantageous for the treatment of tumors that are radio-resistant to conventional radiotherapy
and/or … Comparing clinical results obtained with carbon ion radiotherapy (CIRT) at different …

EUD‐based biological optimization for carbon ion therapy

SC Brüningk, F Kamp, JJ Wilkens - Medical Physics, 2015 - Wiley Online Library
Treatment planning for carbon ion therapy requires an accurate modeling of the biological
… during the optimization, treatment plans were obtained that were of similar quality as the …