[HTML][HTML] Alzheimer's disease hypothesis and related therapies
X Du, X Wang, M Geng - Translational neurodegeneration, 2018 - Springer
… based on these hypotheses have been developed. In this review, we will discuss the existing
and emerging hypothesis and related therapies. Similar content being viewed by others …
and emerging hypothesis and related therapies. Similar content being viewed by others …
Current and future therapy in Alzheimer's disease
RJ Van Marum - Fundamental & clinical pharmacology, 2008 - Wiley Online Library
… Data from animal models support the hypothesis that DHA may be an effective treatment
for … or the cognitive portion of the Alzheimer Disease Assessment Scale. However, positive …
for … or the cognitive portion of the Alzheimer Disease Assessment Scale. However, positive …
[HTML][HTML] Future therapeutic perspectives into the Alzheimer's disease targeting the oxidative stress hypothesis
JP Teixeira, AA de Castro, FV Soares, EFF da Cunha… - Molecules, 2019 - mdpi.com
… -related hypotheses presented here, we highlight in this review the oxidative hypothesis,
which involves important aspects related to … target for drug discovery and modifying therapies. …
which involves important aspects related to … target for drug discovery and modifying therapies. …
Multifactorial hypothesis and multi-targets for Alzheimer's disease
… However, the multifactorial hypothesis of AD that we proposed here is different from those
proposed previously. Our hypothesis emphasizes two key concepts for the development of AD. …
proposed previously. Our hypothesis emphasizes two key concepts for the development of AD. …
[HTML][HTML] History and progress of hypotheses and clinical trials for Alzheimer's disease
PP Liu, Y Xie, XY Meng, JS Kang - … transduction and targeted therapy, 2019 - nature.com
… hypothesis, inflammatory hypothesis, metal ion hypothesis, and lymphatic system hypothesis…
In this review, we discuss the main hypotheses of AD and related clinical trials. Wealthy …
In this review, we discuss the main hypotheses of AD and related clinical trials. Wealthy …
The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development
AV Terry, JJ Buccafusco - … of Pharmacology and Experimental Therapeutics, 2003 - ASPET
… Alzheimer's disease (AD). This premise has since served as the basis for the majority of
treatment … , led some to challenge the validity of the hypothesis as well as the rationale for using …
treatment … , led some to challenge the validity of the hypothesis as well as the rationale for using …
[HTML][HTML] Therapeutics for Alzheimer's disease based on the metal hypothesis
… Hypothesis of Alzheimer's Disease,” which stipulates that the neuropathogenic effects of Aβ
in Alzheimer's disease … promise as disease-modifying agents for Alzheimer's disease based …
in Alzheimer's disease … promise as disease-modifying agents for Alzheimer's disease based …
Treatment of Alzheimer's disease: the legacy of the cholinergic hypothesis, neuroplasticity, and future directions
JW Ashford - Journal of Alzheimer's Disease, 2015 - content.iospress.com
… As of 2015, the main therapy for Alzheimer’s disease (AD) is treatment with an acetyl… treatment,
and it is usually used as a supplement to an AChEI. Currently, the major factor associated …
and it is usually used as a supplement to an AChEI. Currently, the major factor associated …
Revisiting the cholinergic hypothesis in Alzheimer's disease: emerging evidence from translational and clinical research
, … System Working Group, and for the Alzheimer … - … of Alzheimer's disease, 2019 - Springer
… to individual patients at early disease stages (37, 38). The limitations of the amyloid cascade
hypothesis and the failure of several Aβ-focused therapy development efforts, together with …
hypothesis and the failure of several Aβ-focused therapy development efforts, together with …
The cholinergic hypothesis of Alzheimer's disease: a review of progress
PT Francis, AM Palmer, M Snape… - Journal of Neurology …, 1999 - jnnp.bmj.com
… hypothesis of Alzheimers disease” (figure A). Thus it was proposed that degeneration of
cholinergic neurons in the basal forebrain and the associated loss of … with Alzheimer’s disease.9 …
cholinergic neurons in the basal forebrain and the associated loss of … with Alzheimer’s disease.9 …
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