… excretion of a wide variety of xenobiotics, including drugs, metabolites, and toxins, as well as
endogenous compounds. Renal excretion … parameter refinement and developing the model…

… to drug development. This paper describes the development and some verification of a …
the basis for a step towards further verification of this population. The underlying algorithms …

… renal transporters (11 perpetrator drugs considered for qualification during creatinine model
development and verification … filtration rate or creatinine renal excretory clearance (CL R ) >…

… Its elimination is mediated by both hepatic metabolism and renal excretion. Consequently,
its clearance is susceptible to both intrinsic (pathophysiological) and extrinsic (concomitant …

… end-stage renal disease requiring renal replacement therapy … maintained their glomeruli
and renal tubules, with little … excretion channel is indispensable for the development of …

… of which approaches the renal pelvis, forming a papilla. This heterogeneity is caused by
three successive excretory systems that develop during embryonic development; and the latter …

… mice, we developed a HCO 3 - … renal HCO 3 − secretion by the β-ICs is absent in CF mice.
Subsequently, we took a translational approach to verifying a greatly reduced ability to excrete …

… excretion might disappear. This possibility is unfortunately incapable of experimental
verification. … The loss of potassium is frequently associated with the development of hypertonicity …

… renal excretion, despite the fact that 25–30 % of drugs are cleared predominantly by renal
clearance and renal … The following applications of Mech KiM provide performance verification …

… of the mean clearance to the mean renal blood flow. The efficiency of urea excretion,
computed from a mean clearance and a mean renal blood flow from independent sources, shows …