… OTA renal toxicity and carcinogenicity in rodents. As male rats respond with the highest renal
… or more of the mechanisms involved in OTA induced renal tumors in male rats are male rat …

… for Perc-induced renal tumorigenesis are: 1) peroxisome proliferation, 2) α-2u-globulin … be
present in renal cortical mitochondria, a soluble form present in the mitochondrial matrix that is …

… Pregnenolone and progesterone synthesis was evaluated in isolated mitochondria from
renal cortex and medulla. Renal synthesis of these steroids in basal conditions was previously …

… changes associated with mitochondrial biogenesis. PGC-1α acts upstream of Nrf1/Nrf2 and
TFAM and has the capacity to increase mitochondrial DNA levels and mitochondrial mass (52…

… Thus, the precise cell types whose loss of mitochondrial … In mice, decreased mtDNA levels
were visualized in renal tubules … Mitochondria are critical for many cellular functions including …

… mitochondrial homeostasis in RNA extracted from the renal … with β-oxidation and mitochondrial
homeostasis. BTBR WT (open … enzymatic pathways within the mitochondria, serving not …

… The mycotoxin ochratoxin A (OTA) is a potent renal carcinogen in rodents. OTA is only … A
number of mechanisms have been proposed to account for renal tumor formation. DNA adduct …

… sustained tubule cell regeneration associated with α 2u -globulin accumulation), or category
6 (… by renal mitochondrial β-lyase binds to mitochondrial proteins and inhibits mitochondrial …

… renal hypertrophy increases energy demand per nephron, leaving the cells in a
hypermetabolic state with an increased mitochondrial electron transport rate and mitochondrial …

… , mitochondrial transport and catabolism of glutamine are acutely activated (34). The resulting
increases in renal … During chronic metabolic acidosis, the acute decreases in the renal …