Mitochondrial dysfunction in the pathophysiology of renal diseases

R Che, Y Yuan, S Huang… - … of Physiology-Renal …, 2014 - journals.physiology.org
mitochondrial dysfunction plays a critical role in the pathogenesis of kidney diseases. To
illuminate the involvement of mitochondrial dysfunction … Then, mitochondrial cytopathies (MCs) …

Mitochondrial dysfunction in inherited renal disease and acute kidney injury

F Emma, G Montini, SM Parikh, L Salviati - Nature Reviews Nephrology, 2016 - nature.com
… been implicated in various types of renal disorders, both inherited and acquired… mitochondrial
cytopathies that can result in renal disease as well as the role of mitochondrial dysfunction

Mitochondrial dysfunction in diabetic kidney disease

JM Forbes, DR Thorburn - Nature Reviews Nephrology, 2018 - nature.com
Mitochondrial dysfunction is associated with kidney disease in nondiabetic contexts, and
increasing evidence suggests that dysfunctional renal mitochondria … contributes to renal hypoxia…

[HTML][HTML] Mitochondrial dysfunction in kidney injury, inflammation, and disease: Potential therapeutic approaches

D Bhatia, A Capili, ME Choi - Kidney research and clinical practice, 2020 - ncbi.nlm.nih.gov
… We reported that sepsis-induced renal tubular injury and mitochondrial dysfunction
improved in the absence of the necroptosis regulator receptor-interacting protein kinase-3 (RIPK3). …

The not so 'mighty chondrion': emergence of renal diseases due to mitochondrial dysfunction

AM Hall, RJ Unwin - Nephron Physiology, 2006 - karger.com
renal function, and in this article, we draw together the evidence for a link between disordered
mitochondrial function and renal … treat renal disorders related to mitochondrial dysfunction

[HTML][HTML] High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction

Y Sun, X Ge, X Li, J He, X Wei, J Du, J Sun, X Li… - Cell death & …, 2020 - nature.com
… In this study, we set to explore the mechanism whereby HFD promotes renal injury by focusing
on mitochondrial dysfunction, which has been recognized as a critical driver for cell injury …

[HTML][HTML] Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity

LC Cao, TW Honeyman, R Cooney, L Kennington… - Kidney international, 2004 - Elsevier
… promoted ROS formation in isolated renal mitochondria. … cytotoxic effects of oxalate on renal
epithelial cells appear to be … elicit direct effects on renal mitochondrial production of ROS, …

Mitochondrial dysfunction in diabetic kidney disease

PZ Wei, CC Szeto - Clinica Chimica Acta, 2019 - Elsevier
… of CKD, aborting mitochondrial dysfunction prevents renal tubular cell EMT and renal fibrosis
[113,118]. In addition to renal tubular cells, mitochondrial dysfunction in podocyte may also …

Mitochondrial dysfunction and the AKI-to-CKD transition

M Jiang, M Bai, J Lei, Y Xie, S Xu… - … of Physiology-Renal …, 2020 - journals.physiology.org
… of mitochondria in renal recovery after AKI and the progression from AKI to CKD in recent
years. We will highlight the promising effects of targeting mitochondrial dysfunction in …

Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice

A Andres-Hernando, MA Lanaspa… - … Physiology-Renal …, 2019 - journals.physiology.org
Mitochondrial injury often precedes the … , renal mitochondria dysfunction is observed in
patients with sepsis or individuals who died from shock or trauma (27). Mitochondrial dysfunction