… involved in mitochondrial oxidant production and tubular cell damage … kidney proximal
tubular (NRK) cells to study the mechanisms by which hyperglycemia alters renal mitochondrial …

… of MMA renal disease. Our studies suggest proximal tubular mitochondrial dysfunction is
a key pathogenic mechanism of MMA-associated kidney disease, identify lipocalin-2 as a …

… mitochondrial-derived oxidative stress. This study investigated whether mitochondrial dysfunction
… a major regulator of oxidative metabolism and mitochondrial function, prevents EMT by …

… to induce mitochondrial dysfunction by blocking the … mitochondria,Citation 4 and long-term
usage of CsA is often limited by its toxicity to the proximal tubule epithelial cells of the kidney…

… multifaceted role of mitochondria and proximal tubule metabolism in kidney disease and
dysfunction, including the contribution of energy deficit, dysfunctional metabolism, cell death, …

… , proposing a model that nicotinamide mononucleotide (NMN) released by renal proximal
tubule cells (RPTCs) diffuses back to the glomerulus to induce podocyte foot process …

… and reduces tubular injury and mitochondrial dysfunction induced by … proximal tubular cells
[132]. However, trehalose promoted cell death and inflammation in rat kidney epithelial cells […

… and consequent mitochondrial dysfunction during oxidative injury in renal proximal tubule
cells. We employed p66shc knockdown renal proximal tubule cells and cells that overexpress …

… The importance of mitochondrial dysfunction and lipid peroxidation to the resulting … a cellular
level. The purpose of this study was to investigate early alterations in renal proximal tubule …

… of renal proximal tubule epithelial cells (100). The serum uric acid level often precedes the
deterioration of CKD, with about half of patients developing hyperuricemia at the initiation of …