… Although constitutive activating mutations in the Wnt/β-catenin … for β-catenin activation.
Here, we investigated the role of (pro)renin receptor ((P)RR), a component of the Wnt receptor …

… OBJECTIVE The (pro)renin receptor (PRR) plays an essential role in the early development
of the central nervous system by activating the Wnt/b-catenin signaling pathway. The authors …

… We further explored whether renin is required for PRR potentiation of Wnt/β-catenin signaling,
because renin/prorenin binding to PRR is obligatory for PRR-mediated RAS activation …

… Although Wnt/β-catenin signaling is known to be aberrantly activated … /β-catenin activation.
Recent studies have implicated the (pro)renin receptor ((P)RR) is related to the Wnt/β-catenin …

… Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and
prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor …

The extracellular domain of the (pro)renin receptor (PRR) is cleaved to produce a soluble (pro)renin
receptor (sPRR) that is detected in biological fluid and elevated under certain …

… The (pro)renin receptor [(P)RR] binds to prorenin to activate the renin-angiotensin system …
, β-catenin, and Axin2. (P)RR regulates lung development through canonical Wnt/β-catenin …

… (H) Colocalization of β-catenin and various RAS components in ADR nephropathy.
Kidney … for AGT or renin (red) and β-catenin (green). Arrows indicate AGT (or renin) and β-catenin …

(Pro)renin receptor (PRR) expression is upregulated in diabetes. We hypothesized that
PRR contributes to podocyte injury via activation of Wnt-β-catenin-snail signaling pathway. …

… and the canonical WNT/β-catenin pathway. Kidney juxtaglomerular apparatus cells secrete
renin, which is activated by pro-renin receptor (PRR). Renin stimulates the RAS cascade by …