… suggest that (pro)renin receptor is responsible for end-organ damage. … an organdamage
receptor. The present transgenic rat line may be useful for studies of such end-organ damage. …

… renin receptor ((P)RR)—also termed renin/prorenin receptor (RER)—which can specifically
bind prorenin and renin… Interestingly, this receptor—which is expressed in organs such as the …

… critically contribute to the development of hypertension-induced end-organ damage [1,2,3,4]…
development of end-organ damage are mediated via the activation of ET receptors type A (…

… that renin-… renin-angiotensin-aldosterone system (RAAS) imbalance has on health
considerations above and beyond high blood pressure, such as fibrotic end-organ damage…

… The nephroprotective effect of ET receptor blockade in these models is … the renin-angiotensin
system. The beneficial effects of ET receptor blockers in modulating target-organ damage …

… end-organ damage, … end-organ protection. Combining ACE inhibitors and ARBs to provide
more extensive RAS inhibition may provide greater antihypertensive efficacy and end-organ …

… Binding of Wnt to a cell membrane complex comprising Frizzled, LDL receptor-related protein
6 (LRP6), the (pro)renin receptor ((P)RR) and vacuolar H + -ATPase (V-ATPase) induces …

… precursor of renin, in end-organ damage. Binding of renin and prorenin (referred to as (pro)renin) …
However, the (pro)renin concentrations required for intracellular signalling in vitro are …

… We present a critical review on emerging concepts on the role of (pro)renin receptor, (P)RR, …
by the receptor led to nontoxic peptidic prorenin receptor blocker. The receptor blocker …

… renin inhibitor to suppress the reactive rise in renin activity, alone or in combination with ACE
inhibitors or ARB, may have considerable potential for the prevention of end organ damage …