… of small molecule renin/ prorenin receptor blocker (… pharmacological target indicate that
the respective protein can have non-redundant functions [54,55,56]. Therefore, pharmacological …

… Thus, targeting renin uptake would block most tissue RAASs at their initial step. The
handle-region peptide is a prototype of such drugs (207), which are being developed in several labs…

… precursor of renin until the discovery the (pro)renin receptor [(P)RR] … In addition, binding of
renin and prorenin triggers … (pro)renin-(P)RR interaction could be a potential target for treating …

… pharmacological inhibition of V-ATPase 16 , the (P)RR is considered to function as a hinge
molecule between the Wnt receptor and the V-ATPase that mediates Wnt receptor … Wnt target …

… After the discovery of the receptor, (pro)renin receptor antagonists were designed on the
basis of the idea that the prosegment contains a ‘handle’ region that binds to the receptor. …

… Studies of drugs targeting the renin–angiotensin system … receptor blockers had positive
effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin–…

… The renin-angiotensin-aldosterone system has been a highly successful pharmacologic
target, as the system is strongly implicated in the development of hypertension-related target …

… and the broad activity and localization of AT4Rs make it a difficult pharmacological target. …
On the contrary, CYP46A1 activation was studied as a pharmacological target for Alzheimers …

… In fact, pharmacologic interference with RAS activity, by both … binding to cell membrane
receptors by selective antagonists, is … of RAS activity a major target for therapeutic interventions in …

… of cardiovascular and renal diseases, it can be easily understood why it has been long
viewed as the ‘ideal’ target for the pharmacological treatment of several clinical conditions. …