… precursor of renin until the discovery the (pro)renin receptor [(P)RR] … In addition, binding of
renin and prorenin triggers … (pro)renin-(P)RR interaction could be a potential target for treating …

… a major target for therapeutic interventions in these conditions. E-mail: [email protected] … out
that renin-angiotensin system (RAS) activity may represent an ideal target for pharmaceutical …

… effect of renin and its protein precursor, prorenin. The concept that prorenin and renin play a
… (pro) renin receptor ((P) RR), which binds both prorenin and renin with nanomolar affinity, 11…

Background The (pro) renin receptor ((P)RR) plays important roles in various pathways,
such as the Wnt/β-catenin, renin-angiotensin system (RAS), MAPK/ERK and PI3K/AKT/mTOR …

… In the past decade, therapies targeting VEGF-A have revolutionized the treatment of DR;
however, there are several limitations to the therapeutic strategy to inhibit the single molecule in …

… cellular targets. A human (pro)renin receptor ((P)RR)—also termed renin/prorenin receptor
(RER)—which can specifically bind prorenin and renin, has been cloned, consisting of 350 …

… These findings propose ARBs, and, in particular, angiotensin IV/AT4R cascade components,
as promising therapeutic targets for the prevention and treatment of AD-related neuronal …

… therapies targeting this system. Moreover, dual inhibitors which block the RAAS and other
systems involved in the regulation of blood pressure or targeting … RAAS-targeting therapy. …

… the role of RAS in ocular disorders were selected and reviewed thoroughly by the authors
to review RAS-mediated pathogenic mechanisms and therapeutic targets in ocular diseases. …

… have widened the search for possible therapeutic targets in hypertension beyond the classical
… )renin receptor (P)rr was reported by nguyen and colleagues.this receptor binds renin and …