… In §5, we comment on clonal expansion, diversity and overlap. Here, we focus … of the
repertoire as a whole (inter-clonal diversity). In §6, we comment on two general metrics of repertoire …

… Why is the determination of CDR3 size important in T-cell repertoire analyses? Methods of
T-cell repertoire analysis include random sequencing, RNase protection assays”‘xl’, TCR mini…

… These L chains were not found in B cells from any other CSF repertoires analyzed in this
study, and MS02-2 clone 1 was the only clonal population in which we detected multiple …

… Even though diversity contracts with age, we find that elderly individuals still possess a
diverse T-cell repertoire. However, we observe robust clonal expansion with age in the naïve …

… 100 (most expanded) nucleotide clones was calculated per … top 100 clonal expansions in
both the CD4 TCR repertoire (… 11E) and the CD8 TCR repertoire (28.2% in AS patients versus …

… modifications using flow cytometry or Immunoscope provided clear-cut and detailed insight
into the clonal expansion processes during the responses against a defined antigen (64, 66). …

… gestational age, and may contribute substantially to the oligoclonal expansion found in our
study population. We found that clonal expansion appeared equally in the CD4 + and CD8 + …

… analysis performed in this study shows an age-dependent increase in the number of expanded
clones present in the recirculating T cell pool. Hence, a small number of clones accounts …

… in patients with metastatic melanoma treated with immunotherapy drugs, an association
between clonal expansion represented by 1-Pielou’s index and clinical response was …

… cloned and sequenced for the detailed analysis of the VDJ junctions. Our results show a
significant perturbation of the B cell repertoire in … corroborates the clonality initially observed by …