Instability of repetitive DNA sequences: the role of replication in multiple mechanisms
M Bzymek, ST Lovett - … of the National Academy of Sciences, 2001 - National Acad Sciences
… DNA into the appropriate bacterial strains. Uncut and purified pBR322 DNA was transformed
in parallel … coli, mutations in many of the components of the DNA PolIII holoenzyme result in …
in parallel … coli, mutations in many of the components of the DNA PolIII holoenzyme result in …
Substitutions are boring: some arguments about parallel mutations and high mutation rates
… and high rate of per-locus mutation, and are sometimes referred to as ‘repetitive’ DNA … the
modes of mutation demonstrate parallel mutation; that is, their rate of mutation is sufficiently …
modes of mutation demonstrate parallel mutation; that is, their rate of mutation is sufficiently …
Substitutions are boring: some arguments about parallel mutations and repetitive DNA
… ” 6 DNA mutations, in that the affected DNA elements usually exist in high copy numbers in
… the modes of mutation demonstrate 28 parallel mutation; that is, that their rate of mutation is …
… the modes of mutation demonstrate 28 parallel mutation; that is, that their rate of mutation is …
Repetitive DNA and next-generation sequencing: computational challenges and solutions
TJ Treangen, SL Salzberg - Nature Reviews Genetics, 2012 - nature.com
… use of sequencing to discover mutations and structural variants in … algorithms use a variety
of strategies to place repetitive reads. … from massively parallel sequence data. Proc. Natl Acad. …
of strategies to place repetitive reads. … from massively parallel sequence data. Proc. Natl Acad. …
Tandem-repetitive noncoding DNA: forms and forces.
W Stephan - Molecular biology and evolution, 1989 - academic.oup.com
… In parallel, the lengths of the repeat units increase with decreasing recombination frequencies…
mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA. …
mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA. …
Why repetitive DNA is essential to genome function
JA Shapiro, R von Sternberg - Biological Reviews, 2005 - cambridge.org
… Repetitive DNA sequence elements are also … repetitive DNA in many genomes, describe
its structural diversity, and discuss dozens of cases where the functional importance of repetitive …
its structural diversity, and discuss dozens of cases where the functional importance of repetitive …
On simple repetitive DNA sequences and complex diseases
C Epplen, EJM Santos, W Mäueler… - …, 1997 - Wiley Online Library
… to their influences on the DNA structure, gene expression, … Grossly differing mutation rates
are evident in these elements … A parallel candidate gene approach was targeted on the …
are evident in these elements … A parallel candidate gene approach was targeted on the …
Rates and Patterns of Mutation in Tandem Repetitive DNA in Six Independent Lineages of Chlamydomonas reinhardtii
JM Flynn, SE Lower, DA Barbash… - Genome Biology and …, 2018 - academic.oup.com
… , mutation rates as opposed to natural selection remains an open question. Tandem repetitive
DNA might experience different mutation … processes generating satellite DNA variation is …
DNA might experience different mutation … processes generating satellite DNA variation is …
Selection Constrains High Rates of Tandem Repetitive DNA Mutation in Daphnia pulex
… -genome sequences of 28 mutation accumulation (MA) … mutation rates of abundances of
repeat sequences and evaluate the selective regime acting upon them. We found that mutation …
repeat sequences and evaluate the selective regime acting upon them. We found that mutation …
[16] Evolutionary analyses of repetitive DNA sequences
MA Batzer, CW Schmid, PL Deininger - Methods in enzymology, 1993 - Elsevier
… changes may occur in parallel in totally different members of a family… parallel changes in
random family members (Fig. 1A). For example, position 143 in Fig. 1A shows parallel mutations …
random family members (Fig. 1A). For example, position 143 in Fig. 1A shows parallel mutations …
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