Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by …

HK Jyrkkänen, S Kuosmanen, M Heinäniemi… - Biochemical …, 2011 - portlandpress.com
BACH1 is a repressor of transcription via competitive binding to the MARE (Maf-… BACH1
is a transcriptional repressor that is regulated at multiple levels. Haem binds to BACH1 and …

Redox regulation of the transcriptional repressor Bach1

M Ishikawa, S Numazawa, T Yoshida - Free Radical Biology and Medicine, 2005 - Elsevier
Bach1 is a transcriptional repressor of heme oxygenase-1, one of the most inducible phase
2 proteins. Bach1 … protein to tandem repeats of the antioxidant response element (ARE) and …

Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate …

JW Kaspar, AK Jaiswal - Journal of Biological Chemistry, 2010 - ASBMB
Bach1, a transcriptional repressor of the heme oxygenase gene, localizes in the nucleus
under normal conditions. The heavy metal cadmium and heme induced chromosomal region …

[HTML][HTML] Bach1: function, regulation, and involvement in disease

X Zhang, J Guo, X Wei, C Niu, M Jia, Q Li… - Oxidative medicine and …, 2018 - hindawi.com
Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1
that allows Nrf2 to bind to the antioxidant response … of the transcriptional repressor BACH1 by …

… regulation of the antioxidant response element (ARE)-mediated NAD (P) H: quinone oxidoreductase 1 gene expression and induction in response to antioxidants

S Dhakshinamoorthy, AK Jain, DA Bloom… - Journal of Biological …, 2005 - ASBMB
… The heavy metal cadmium induced the nuclear export of Bach1, a transcriptional repressor
… in response to antioxidants. We demonstrate that overexpression of Bach1 represses …

BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite

JF Reichard, MA Sartor, A Puga - Journal of biological chemistry, 2008 - ASBMB
… and that BACH1 inactivation is … BACH1 is thought to interact with antioxidant response
element motifs, we further examined the role of BACH1 as a regulator of inducible antioxidant

The Bach family of transcription factors: a comprehensive review

Y Zhou, H Wu, M Zhao, C Chang, Q Lu - Clinical reviews in allergy & …, 2016 - Springer
… The inactivation of Bach1 exerts an antioxidant effect. … repressor effect of Bach1 exceeds
the activator effect of HO-1 [6, 23]. On the other hand, heme can inhibit the functions of Bach1 [23…

Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neurons

EA Waxman - BioRxiv, 2019 - biorxiv.org
… transcriptional repressors Bach1 and Bach2 that inhibit Nrf2 responses and prevent antioxidant
… in dopaminergic neurons in mediating Nrf2 antioxidant responses. We hypothesized that …

Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1

JF Reichard, GT Motz, A Puga - Nucleic acids research, 2007 - academic.oup.com
… To characterize activation of the antioxidant response following arsenite exposure, we first
characterized cellular and subcellular changes in NRF2 and BACH1 disposition. In control …

BACH1 mediates the antioxidant properties of aged garlic extract

T Tsuneyoshi - Experimental and Therapeutic …, 2020 - spandidos-publications.com
… the Nrf2‑dependent antioxidant response. Neither S1PC nor SAC … 1 (BACH1), a transcriptional
repressor that competes with … Nrf2 binds to antioxidant response elements (AREs) that are …