Role of Bach1 and Nrf2 in up‐regulation of the heme oxygenase‐1 gene by cobalt protoporphyrin
Y Shan, RW Lambrecht, SE Donohue… - The FASEB …, 2006 - Wiley Online Library
… , but also from the production of biliverdin and bilirubin, both potent antioxidants. …
Schematic model of actions of repressors and inducers of HO-1 via regulation of Bach1 and …
Schematic model of actions of repressors and inducers of HO-1 via regulation of Bach1 and …
Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, β-globin, and NADP …
KJ Hintze, Y Katoh, K Igarashi, EC Theil - Journal of Biological Chemistry, 2007 - ASBMB
… that modulation of cellular Bach1 concentrations will have … /antioxidant response elements
in iron/oxygen/antioxidant … demonstrated that Bach1 was the heme-reversible repressor. In …
in iron/oxygen/antioxidant … demonstrated that Bach1 was the heme-reversible repressor. In …
Challenges and limitations of targeting the Keap1-Nrf2 pathway for neurotherapeutics: Bach1 de-repression to the rescue
DM Hushpulian, N Ammal Kaidery, M Ahuja… - Frontiers in aging …, 2021 - frontiersin.org
… targeting Keap1 is to inhibit the Nrf2 repressor Bach1 for constitutive activation of the Nrf2 …
By binding the antioxidant response elements (ARE) in promoter regions, Nrf2 regulates the …
By binding the antioxidant response elements (ARE) in promoter regions, Nrf2 regulates the …
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle
… antioxidant response genes. To systematically address the gene regulatory networks involving
BACH1… of heme levels by BACH1, an analogy with the lac repressor sensitivity to lactose, …
BACH1… of heme levels by BACH1, an analogy with the lac repressor sensitivity to lactose, …
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome
S Pagnotta, A Tramutola, E Barone… - Free Radical Biology …, 2022 - Elsevier
… BACH1 overexpression alters the BACH1/NRF2 ratio in the nucleus and disturbs the induction
of antioxidant response … In this frame, BACH1, a transcription repressor that acts as a key …
of antioxidant response … In this frame, BACH1, a transcription repressor that acts as a key …
Inhibiting BTB domain and CNC homolog 1 (Bach1) as an alternative to increase Nrf2 activation in chronic diseases
D Mafra, L Alvarenga, LFMF Cardozo… - … et Biophysica Acta (BBA …, 2022 - Elsevier
… antioxidant responses in the chronic burden of lifestyle diseases, including chronic kidney
disease. Thus, this review will discuss the status of Bach1 in … Bach1 expression (repressor of …
disease. Thus, this review will discuss the status of Bach1 in … Bach1 expression (repressor of …
Hepatocyte‐specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up‐regulation of Bach1, an Nrf2 repressor
SO Ka, IH Bang, EJ Bae, BH Park - The FASEB Journal, 2017 - Wiley Online Library
… , BTB domain and CNC homolog 1 (Bach1), a nuclear repressor of Nrf2, were up-regulated. …
with Bach1 under basal condition, induces its detachment from the antioxidant response …
with Bach1 under basal condition, induces its detachment from the antioxidant response …
Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy
D Hu, Z Zhang, X Luo, S Li, J Jiang, J Zhang, Z Wu… - Biomarker …, 2024 - Springer
… gene MLH1 and other target tumor repressor genes containing CIMP. In turn, … BACH1
directly suppresses the expression of the CFTR gene by binding to its -44kb antioxidant response …
directly suppresses the expression of the CFTR gene by binding to its -44kb antioxidant response …
Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels
SJ Chapple, TP Keeley, D Mastronicola, M Arno… - Free Radical Biology …, 2016 - Elsevier
… repressor Bach1 is elevated in human umbilical vein (HUVEC) and coronary artery (HCAEC)
EC adapted to 5% O 2 . Knockdown of Bach1 … of Nrf2-regulated antioxidant defenses under …
EC adapted to 5% O 2 . Knockdown of Bach1 … of Nrf2-regulated antioxidant defenses under …
Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the" one-two" punch
K Srisook, C Kim, YN Cha - Antioxidants & redox signaling, 2005 - liebertpub.com
… the transcriptional activator Nrf2 or the transcriptional repressor Bach1 (44, 71). To assess
the … antioxidant response elements. Biochem Biophys Res Commun 236: 313–322, 1997. 51. …
the … antioxidant response elements. Biochem Biophys Res Commun 236: 313–322, 1997. 51. …