… chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls …

AK MacLeod, M McMahon, SM Plummer… - …, 2009 - academic.oup.com
… stressors through the presence of antioxidant response elements (AREs, … BACH1 also
regulates ARE-driven genes, we have also knocked down this BTB-CNC transcriptional repressor

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson's Disease

M Ahuja, NA Kaidery, D Dutta, OC Attucks, EH Kazakov… - Antioxidants, 2022 - mdpi.com
… transcriptional repressor of BTB and CNC homology 1 (Bach1)… genes that harbor cis-
antioxidant response element (ARE) … in the antioxidant, anti-inflammatory responses, …

Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA–(antioxidant response elements) and mRNA (iron responsive elements) sequences

EC Theil - Journal of inorganic biochemistry, 2006 - Elsevier
… (AREs: Antioxidant Response Elements, in genes … repressors: IRP1 or IRP2:IRE-RNA
and Bach1:ARE-DNA that are modulated by direct signals such as heme-repressor binding (Bach1

BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells

B Yao, Y Cai, L Wan, J Deng, L Zhao… - The Journal of Gene …, 2023 - Wiley Online Library
BACH1 is a transcriptional repressor of HMOX1. The high expression of HMOX1 may … ,
BACH1 has an endogenous heme ligand that inhibits BACH1 binding to antioxidant response

Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway

J Alam, JL Cook - Current pharmaceutical design, 2003 - ingentaconnect.com
… if Bach1 functions as a ubiquitous and dominant repressor of the hmox1 gene, whether
inactivation of this repressor … Functional characterization and role of INrf2 in antioxidant response

MicroRNA-98-5p ameliorates oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury by inhibiting Bach1 and promoting Nrf2/ARE signaling

X Sun, X Li, S Ma, Y Guo, Y Li - Biochemical and Biophysical Research …, 2018 - Elsevier
… of the antioxidant response element (ARE). However, overexpression of Bach1 or silencing
of … However, Bach1 functions as a transcriptional repressor of Nrf2 by competitively binding to …

Remifentanil represses oxidative stress to relieve hepatic ischemia/reperfusion injury via regulating BACH1/PRDX1 axis

Y You, S Chen, H Deng, X Xing, B Tang, Y Wu… - Clinics and Research in …, 2024 - Elsevier
BACH1 can repress the transcription and expression of antioxidant genes through binding to
the antioxidant … In this study, we aimed to verify whether RE treatment could restrain BACH1

MO565: Evaluation of Bach1 Mrna Expression (Repressor of NRF2) in Patients With Chronic Kidney Disease

D Mafra, L Alvarenga, B G. Baptista… - Nephrology Dialysis …, 2022 - academic.oup.com
… binds to genomic DNA and can inhibit the synthesis of antioxidant enzymes, increasing …
reported on Bach1 in patients with CKD. This study aimed to evaluate Bach1 mRNA expression …

microRNA-494 favors HO-1 expression in neuroblastoma cells exposed to oxidative stress in a bach1-independent way

S Piras, AL Furfaro, R Caggiano, L Brondolo… - Frontiers in …, 2018 - frontiersin.org
… Thus, we evaluated miR-494 which, from bioinformatics analyses, was predicted to have
two putative binding sites on Bach1 3′UTR, the main repressor of HO-1 transcription. …

[HTML][HTML] The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity

L Casares, R Moreno, KX Ali, M Higgins, SD Naidu… - Redox Biology, 2022 - Elsevier
BACH1 is a transcriptional repressor of heme oxygenase 1 (… of HMOX1 is also regulated by
BACH1 (broad complex, … binding to sequences called antioxidant response elements (AREs) …