… Bach1 and Bach2, in higher eukaryotes. Heme inhibits the transcriptional repressor activity
of Bach1, … Tyrosine 486 of Bach1 is phosphorylated in response to the antioxidant tert-…

… The cessation of HO-1 induction occurred at the transcriptional and translational levels,
and was mediated by the activation of the heme-binding transcriptional repressor Bach1 and …

… reduced Bach1 and increased NRF2 binding to the γ-globin promoter antioxidant response
… The transcription repressor Bach1 is a potential therapeutic target for a variety of chronic …

… and the nuclear repressor BTB and CNC homology 1 (BACH1), … with LPS exhibit changes in
BACH1 and HO-1 expression. … BACH1 with the master regulator of the antioxidant response, …

… the antioxidant response eg, ferroportin 1, heme oxygenase 1, superoxide dismutase, etc.
The repressor protein, Bach1, … However, in the presence of heme, Bach1 binds to heme and …

… Thus, HO-1 is an antioxidant defense enzyme … the repressor Bach1 in distinct ways to achieve
conditional gene expression and suggest that the interpretation of various stimuli by Bach1 …

… Nrf2 regulates gene expression via an antioxidant response … antioxidant response element
mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 …

… of BACH1. It was found that MCAO/R mice expressed much higher BACH1 in the brain tissues
accompanied with severe cerebral infarction, whereas downregulation of BACH1 reduced …

… Bach1 is a repressor of specific genes targeted by Nrf2, hindering nuclear translocation and
the action of this crucial antioxidant … Nrf2-mediated antioxidant responses. However, our …

… regulated by the antioxidant response element (ARE) of the … Nrf2, but not on the repressor
Bach1. Results obtained with … HMOX1 expression on the repressor Bach1 in order to evaluate …