Emerging therapies in Parkinson disease—repurposed drugs and new approaches
… compounds, repurposed drugs and new technologies. In this Review, we focus on disease-…
We review cellular therapies and repurposed drugs, such as nilotinib, inosine, isradipine, …
We review cellular therapies and repurposed drugs, such as nilotinib, inosine, isradipine, …
Drug repurposing strategies of relevance for Parkinson's disease
EJR Fletcher, T Kaminski, G Williams… - Pharmacology …, 2021 - Wiley Online Library
… drugs so the disease progresses unchecked. Standard drug discovery programs for disease…
provided key insights into the pathogenesis of Parkinson's disease but, of the many positive …
provided key insights into the pathogenesis of Parkinson's disease but, of the many positive …
What to test in Parkinson disease prevention trials? Repurposed, low-risk, and gene-targeted drugs
GF Crotty, MA Schwarzschild - Neurology, 2022 - AAN Enterprises
… underpinning numerous “disease modification” trials in manifest Parkinson disease (PD), …
therapies earlier in the disease. In this article, we outline the principles of drug selection for PD …
therapies earlier in the disease. In this article, we outline the principles of drug selection for PD …
Recent advances in drug repurposing for Parkinson's disease
X Chen, G Gumina, KG Virga - Current Medicinal Chemistry, 2019 - ingentaconnect.com
… drug repurposing. With the successful clinical introduction of several repurposed drugs for
Parkinson’s disease, drug repurposing … development of novel drugs for this disease. In this …
Parkinson’s disease, drug repurposing … development of novel drugs for this disease. In this …
Repurposing drugs to treat neurological diseases
TH Massey, NP Robertson - Journal of neurology, 2018 - Springer
… /compound libraries to search for potential therapeutic activities relating to either Parkinson’s
disease or Zika virus infection of neurons, respectively. The third paper reports a clinical …
disease or Zika virus infection of neurons, respectively. The third paper reports a clinical …
Drug repurposing in Parkinson's disease
D Athauda, T Foltynie - CNS drugs, 2018 - Springer
… repurposed drugs that are currently being evaluated in clinical trials for their potential disease…
Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a …
Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a …
Parkinson's disease drug development since 1999: A story of repurposing and relative success
… We examined the ICTRP to determine the characteristics of Parkinson’s disease trials … the
history of drug development in Parkinson’s disease, characterize trends in drug development, …
history of drug development in Parkinson’s disease, characterize trends in drug development, …
Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease
… discuss the opportunity for repurposing drugs for use in l-DOPA-induced dyskinesia (LID)
in Parkinson's disease. LID is a particularly suitable indication for drug repurposing given its …
in Parkinson's disease. LID is a particularly suitable indication for drug repurposing given its …
Metformin repurposing for Parkinson disease therapy: opportunities and challenges
… diseases has been proposed [8], making metformin one of the most promising drugs for
repurposing… In this review, we will analyze the therapeutic potentials of metformin repurposing for …
repurposing… In this review, we will analyze the therapeutic potentials of metformin repurposing for …
CNS repurposing-Potential new uses for old drugs: examples of screens for Alzheimer's disease, Parkinson's disease and spasticity
CG Parsons - Neuropharmacology, 2019 - Elsevier
… These include 1) target selectivity 2) drug metabolism and pharmacokinetics (DMPK…
repurposed drug eg it does not even have to be selective if it is effective and safe. In fact, dirty drugs …
repurposed drug eg it does not even have to be selective if it is effective and safe. In fact, dirty drugs …
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