… compounds, repurposed drugs and new technologies. In this Review, we focus on disease-…
We review cellular therapies and repurposed drugs, such as nilotinib, inosine, isradipine, …

… drugs so the disease progresses unchecked. Standard drug discovery programs for disease…
provided key insights into the pathogenesis of Parkinson's disease but, of the many positive …

… underpinning numerous “disease modification” trials in manifest Parkinson disease (PD), …
therapies earlier in the disease. In this article, we outline the principles of drug selection for PD …

… drug repurposing. With the successful clinical introduction of several repurposed drugs for
Parkinson’s disease, drug repurposing … development of novel drugs for this disease. In this …

… /compound libraries to search for potential therapeutic activities relating to either Parkinson’s
disease or Zika virus infection of neurons, respectively. The third paper reports a clinical …

… repurposed drugs that are currently being evaluated in clinical trials for their potential disease…
Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a …

… We examined the ICTRP to determine the characteristics of Parkinson’s disease trials … the
history of drug development in Parkinson’s disease, characterize trends in drug development, …

… discuss the opportunity for repurposing drugs for use in l-DOPA-induced dyskinesia (LID)
in Parkinson's disease. LID is a particularly suitable indication for drug repurposing given its …

… diseases has been proposed [8], making metformin one of the most promising drugs for
repurposing… In this review, we will analyze the therapeutic potentials of metformin repurposing for …

… These include 1) target selectivity 2) drug metabolism and pharmacokinetics (DMPK…
repurposed drug eg it does not even have to be selective if it is effective and safe. In fact, dirty drugs …