Eliminating minimal residual disease as a therapeutic end point: working toward cure for patients with CLL

PA Thompson, WG Wierda - … Journal of the American Society of …, 2016 - ashpublications.org
… , so-called minimal residual disease (MRD). These residual cells ultimately are responsible
… on the quantity of residual disease and kinetics of residual leukemia cell division. Sensitive …

Assessment of minimal residual disease in standard-risk AML

A Ivey, RK Hills, MA Simpson… - … England Journal of …, 2016 - Mass Medical Soc
… defined with the use of leukemia-specific molecular markers (… levels of leukemia, so-called
minimal residual disease, after … Patients with minimal residual disease in peripheral blood …

Chronic lymphocytic leukemia therapy guided by measurable residual disease

T Munir, DA Cairns, A Bloor, D Allsup… - … England Journal of …, 2024 - Mass Medical Soc
… We previously assessed ibrutinib plus venetoclax in patients with relapsed–refractory CLL,
with the duration of therapy defined by the time to undetectable measurable residual disease (…

[HTML][HTML] Measurable residual disease in acute lymphoblastic leukemia: methods and clinical context in adult patients

C Saygin, J Cannova, W Stock, L Muffly - Haematologica, 2022 - ncbi.nlm.nih.gov
… as a method of measurable residual disease detection in acute lymphoblastic leukemia. An
patient with B-cell acute lymphoblastic leukemia (B-ALL). The measurable residual disease (…

Acute lymphoblastic leukemia: monitoring minimal residual disease as a therapeutic principle

M Brüggemann, N Gökbuget, M Kneba - Seminars in oncology, 2012 - Elsevier
… cytometric techniques for the quantitative detection of residual leukemic cells, the presence
of minimal residual disease (MRD) in patients in complete clinical remission has clearly been …

Minimal residual disease studies in acute leukemia

D Campana - Pathology Patterns Reviews, 2004 - academic.oup.com
… by morphologic examination was 30.0% ± 17.7% for patients who had residual disease of
0.1% or more in the postinduction 1 sample and 72.1% ± 11.5% for those who had fewer or no …

Measurable residual disease as a biomarker in acute myeloid leukemia: theoretical and practical considerations

RB Walter, Y Ofran, A Wierzbowska, F Ravandi… - Leukemia, 2021 - nature.com
… ”) residual disease (MRD) in acute myeloid leukemia (AML). Although the perfect MRD test
does not (yet) exist, the strong association between MRD and adverse patient outcomes has …

High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival

A Van Rhenen, N Feller, A Kelder, AH Westra… - Clinical cancer …, 2005 - AACR
… In most cases, patients can be treated effectively with chemotherapy … leukemic cells, called
minimal residual disease (MRD; refs. 2–5). MRD can be detected in the majority of patients in (…

WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia

K Inoue, H Sugiyama, H Ogawa, M Nakagawa… - 1994 - ashpublications.org
… minimal residual disease (MRD) in acute leukemia regardless … mRNA was performed for 9
patients with acute leukemia. In 4 … from leukemia patients at the onset of their disease before …

Minimal residual disease in acute myeloid leukaemia

CS Hourigan, JE Karp - Nature reviews Clinical oncology, 2013 - nature.com
… Minimal residual disease measurement during or … patients to identify those most likely to
benefit from escalated or additional therapy For patients in complete remission minimal disease