… Here, we focus on the role of MAPK pathways in modulating drug sensitivity and resistance
… -regulated kinase (ERK) pathway, but mainly focus on the mechanisms how stress activated …

… MAPK pathway reactivation and PI3K pathway activation through secondary mutations in a
patient with acquired resistance … confirmed resistance to MAPK single pathway inhibition was …

… A common theme among the resistance mechanisms is the reactivation of the MAPK … of
resistance in addition to the MAPK pathway. The existence of several resistance mechanisms …

… is released or attenuated by BRAF inhibitors (BRAFis), activation dependent on RTK–ligand
signalling becomes again an important mechanism of MAPK pathway activation, leading to …

… MAPK pathway-directed targeted therapy… MAPK pathway-activating alterations. Collectively,
these data suggest that a subset of patients will develop off-target mechanisms of resistance …

… of resistance mechanisms in melanoma The number of suggested resistance mechanisms
to MAPK pathway … These mechanisms can be subdivided into genomic vs phenotypic …

… pathway activation. A broad cataloging of these and other emerging resistance mechanisms
in … into the heterogeneity of MAPK pathway inhibitor resistance and ultimately enhance the …

… in NSCLC cell line models, we aim to: 1) identify novel mechanisms of adaptive and acquired
resistance … We concluded that the resistant mechanisms for ER1-3 were yet to be identified. …

… the molecular mechanisms underlying MAPK functions in plant disease resistance. …
MAPKs are also implicated in JA and SA signaling pathways. Question marks indicate unknown …

… MAPK pathways composed of 4 signaling families: the MAPK/ERK family or classical pathway
and the Big MAP kinase-1 (BMK-… Multiple secondary mechanisms of resistance have been …