… sequencing to explore the mechanisms of primary resistance by analyzing 11 patients with
primary resistance … Next-generation targeted sequencing was performed on the Illumina X …

… Among our ROS1 + patients, exons 36–42 were sequenced by NGS and/or direct sequencing
to evaluate for the presence of KDM. The average read-depth for these exons was greater …

… mechanisms have been confirmed in multiple patients. From whole-exome sequencing of
6 … were genetically characterized using targeted deep sequencing at baseline and relapse, …

… Large-scale sequencing of patient-derived cancer samples has identified several …
mechanisms, posing a major clinical hurdle for effective treatment. Several resistance mechanisms, …

… One-hundred and fifty two patients with activating EGFR mutations were included in this
study and 136 patients' tumor sample were available for targeted sequencing of genomic …

… Altogether, this study demonstrates that target enrichment coupled with high-throughput
sequencing is a powerful tool for pinpointing genomic changes associated with adaptive traits …

… changes on drug resistance. Here we describe the results from deep-sequencing of RNA …
Candidate target sequences for CRISPR were designed using ZiFiT Targeter Version 4.2 (…

… DNA (cfDNA), targeting 416 cancer-related genes using next generation sequencing. We …
types and investigated potential mechanisms that confer primary resistance to EGFR-TKIs in …

… With the emergence and development of gene detection, liquid biopsy ctDNA technology,
and single-cell sequencing technology, the molecular mechanism of tumor drug …

… it leads to incomplete molecular response to targeted therapies, and proposes the … sequencing
to discover the link between intratumoral heterogeneity and early adaptive drug resistance…