Heterogeneity in multiple sclerosis: scratching the surface of a complex disease
G Disanto, AJ Berlanga, AE Handel… - Autoimmune …, 2011 - Wiley Online Library
… These observations lead us to conclude that despite the wide heterogeneity, there is …
responses. This is likely to lead to the wide clinical, pathological, and immunological heterogeneity …
responses. This is likely to lead to the wide clinical, pathological, and immunological heterogeneity …
Response heterogeneity with exercise training and physical activity interventions among persons with multiple sclerosis
JF Baird, RW Motl - Neurorehabilitation and neural repair, 2019 - journals.sagepub.com
… Such “response heterogeneity” is considered pervasive among all groups of individuals (eg, …
This article presents an argument that researchers should examine response heterogeneity …
This article presents an argument that researchers should examine response heterogeneity …
Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy
H Lassmann, W Brück, C Lucchinetti - Trends in molecular medicine, 2001 - cell.com
… The heterogeneity in the pathology of MS could form the basis of both the polygenic nature
… heterogeneity of the disease with respect to clinical presentation and response to therapy. …
… heterogeneity of the disease with respect to clinical presentation and response to therapy. …
Modeling the heterogeneity of multiple sclerosis in animals
SB Simmons, ER Pierson, SY Lee, JM Goverman - Trends in immunology, 2013 - cell.com
… heterogeneity in the responses of resident cells in the brain and spinal cord. It remains to
be determined whether these findings translate to humans and/or whether there are other …
be determined whether these findings translate to humans and/or whether there are other …
Response heterogeneity in a randomized controlled trial of telerehabilitation interventions among adults with multiple sclerosis
M Plow, RW Motl, M Finlayson… - Journal of telemedicine …, 2022 - journals.sagepub.com
… among baseline characteristics, telerehabilitation and response heterogeneity. We discuss
how research on examining response heterogeneity may be advanced by conducting mega-…
how research on examining response heterogeneity may be advanced by conducting mega-…
Predicting responders to therapies for multiple sclerosis
J Rio, M Comabella, X Montalban - Nature Reviews Neurology, 2009 - nature.com
… The mechanisms underlying heterogeneity in the treatment response are not completely
understood, although genetic factors probably have an important role. Given the complex …
understood, although genetic factors probably have an important role. Given the complex …
Response heterogeneity to home-based restorative cognitive rehabilitation in multiple sclerosis: An exploratory study
… Disease course and treatment response heterogeneity. Greater post-rehabilitation …
These differences and response heterogeneity between the PMS and RRMS participants …
These differences and response heterogeneity between the PMS and RRMS participants …
Assessing heterogeneity of treatment effect in multiple sclerosis trials
MP Sormani, J Chataway, DM Kent… - Multiple Sclerosis …, 2023 - journals.sagepub.com
… to be heterogeneous. This heterogeneity may also extend to therapeutic responses and
adverse effects and can be accounted for by multiple factors including genetic differences, as …
adverse effects and can be accounted for by multiple factors including genetic differences, as …
T-cell specificity influences disease heterogeneity in multiple sclerosis
C Cruciani, M Puthenparampil… - Neurology …, 2021 - AAN Enterprises
… MS, we studied their link with features of disease heterogeneity. We identified patients with
different CSF-infiltrating CD4 + T-cell responses against myelin and GDP-L-FS peptides and …
different CSF-infiltrating CD4 + T-cell responses against myelin and GDP-L-FS peptides and …
Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients
H Hegen, I Adrianto, CJ Lessard… - Neuroimmunology & …, 2016 - AAN Enterprises
… IFN-β response. Relapsing-remitting multiple sclerosis (RRMS) is a heterogeneous disease
that … There is a wide variation in treatment response to therapies including interferon (IFN)–β. …
that … There is a wide variation in treatment response to therapies including interferon (IFN)–β. …
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