Heterogeneity in multiple sclerosis: scratching the surface of a complex disease

G Disanto, AJ Berlanga, AE Handel… - Autoimmune …, 2011 - Wiley Online Library
… These observations lead us to conclude that despite the wide heterogeneity, there is …
responses. This is likely to lead to the wide clinical, pathological, and immunological heterogeneity

Response heterogeneity with exercise training and physical activity interventions among persons with multiple sclerosis

JF Baird, RW Motl - Neurorehabilitation and neural repair, 2019 - journals.sagepub.com
… Such “response heterogeneity” is considered pervasive among all groups of individuals (eg, …
This article presents an argument that researchers should examine response heterogeneity

Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy

H Lassmann, W Brück, C Lucchinetti - Trends in molecular medicine, 2001 - cell.com
… The heterogeneity in the pathology of MS could form the basis of both the polygenic nature
heterogeneity of the disease with respect to clinical presentation and response to therapy. …

Modeling the heterogeneity of multiple sclerosis in animals

SB Simmons, ER Pierson, SY Lee, JM Goverman - Trends in immunology, 2013 - cell.com
heterogeneity in the responses of resident cells in the brain and spinal cord. It remains to
be determined whether these findings translate to humans and/or whether there are other …

Response heterogeneity in a randomized controlled trial of telerehabilitation interventions among adults with multiple sclerosis

M Plow, RW Motl, M Finlayson… - Journal of telemedicine …, 2022 - journals.sagepub.com
… among baseline characteristics, telerehabilitation and response heterogeneity. We discuss
how research on examining response heterogeneity may be advanced by conducting mega-…

Predicting responders to therapies for multiple sclerosis

J Rio, M Comabella, X Montalban - Nature Reviews Neurology, 2009 - nature.com
… The mechanisms underlying heterogeneity in the treatment response are not completely
understood, although genetic factors probably have an important role. Given the complex …

Response heterogeneity to home-based restorative cognitive rehabilitation in multiple sclerosis: An exploratory study

TA Fuchs, S Ziccardi, MG Dwyer, LE Charvet… - Multiple Sclerosis and …, 2019 - Elsevier
… Disease course and treatment response heterogeneity. Greater post-rehabilitation …
These differences and response heterogeneity between the PMS and RRMS participants …

Assessing heterogeneity of treatment effect in multiple sclerosis trials

MP Sormani, J Chataway, DM Kent… - Multiple Sclerosis …, 2023 - journals.sagepub.com
… to be heterogeneous. This heterogeneity may also extend to therapeutic responses and
adverse effects and can be accounted for by multiple factors including genetic differences, as …

T-cell specificity influences disease heterogeneity in multiple sclerosis

C Cruciani, M Puthenparampil… - Neurology …, 2021 - AAN Enterprises
… MS, we studied their link with features of disease heterogeneity. We identified patients with
different CSF-infiltrating CD4 + T-cell responses against myelin and GDP-L-FS peptides and …

Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients

H Hegen, I Adrianto, CJ Lessard… - Neuroimmunology & …, 2016 - AAN Enterprises
… IFN-β response. Relapsing-remitting multiple sclerosis (RRMS) is a heterogeneous disease
that … There is a wide variation in treatment response to therapies including interferon (IFN)–β. …