Understanding patterns of pathologic response following neoadjuvant immunotherapy for solid tumors

LM Sholl - Annals of Oncology, 2018 - annalsofoncology.org
response in the neoadjuvant setting highlights the importance of pathology in response
adequate sampling and reproducible response scoring. To date, few systems of pathologic …

Neoadjuvant checkpoint blockade for cancer immunotherapy

SL Topalian, JM Taube, DM Pardoll - Science, 2020 - science.org
… The immunologic effects of the PD-1 pathway on T cell priming, effector function, and
exhaustion suggest distinct mechanisms underlying neoadjuvant immunotherapy versus …

[HTML][HTML] Multiomics analysis reveals a distinct response mechanism in multiple primary lung adenocarcinoma after neoadjuvant immunotherapy

C Zhang, K Yin, SY Liu, LX Yan, J Su… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
… Since the development of neoadjuvant immunotherapy for … the feasibility of neoadjuvant
immunotherapy in MPLC. Here, … neoadjuvant pembrolizumab, and showing mixed response. …

Neoadjuvant immunotherapy for high-risk, resectable malignancies: scientific rationale and clinical challenges

M Krishnamoorthy, JG Lenehan… - JNCI: Journal of the …, 2021 - academic.oup.com
… the cellular mechanisms that occur during successful neoadjuvant immunotherapy and
highlights … Here we also discuss strategies required for successful neoadjuvant immunotherapy, …

The promise of neoadjuvant immunotherapy and surgery for cancer treatment

JS O'Donnell, EP Hoefsmit, MJ Smyth, CU Blank… - Clinical Cancer …, 2019 - AACR
… setting and its potential mechanism of action. We will also highlight the potential caveats
of neoadjuvant immunotherapy and the questions that remain to be answered using this …

[HTML][HTML] Neoadjuvant immunotherapy is reshaping cancer management across multiple tumour types: The future is now!

M Maio, C Blank, A Necchi, AM Di Giacomo… - European Journal of …, 2021 - Elsevier
… remain an important tool to study underlying mechanisms of treatment resistance and can …
of responses to immunotherapies in cancer, the members reviewed the underlying mechanism

Neoadjuvant immune checkpoint blockade: a window of opportunity to advance cancer immunotherapy

SL Topalian, PM Forde, LA Emens, M Yarchoan… - Cancer cell, 2023 - cell.com
… possibly supporting the hypothesized immunologic mechanisms underpinning neoadjuvant
ICB and validating pathologic response as an early surrogate endpoint for long-term clinical …

[HTML][HTML] Neoadjuvant immunotherapy in non-small cell lung cancer: a narrative review on mechanisms, efficacy and safety

L Shao, G Lou - Journal of Thoracic Disease, 2022 - ncbi.nlm.nih.gov
neoadjuvant immunotherapy is a promising therapeutic strategy for resectable NSCLC patients,
with long-term response … pathologic response of neoadjuvant immunotherapy ranged up …

Immune mechanisms and predictive biomarkers related to neoadjuvant immunotherapy response in stage III melanoma

AB Figueiredo, MJB e Silva, GF de Britto Evangelista… - Heliyon, 2024 - cell.com
… for understanding immune mechanisms behind failure and … as predictive tools for treatment
response. Furthermore, CD95 … and melanoma response to neoadjuvant immune checkpoint …

[HTML][HTML] Neoadjuvant immunotherapy of locoregionally advanced solid tumors

AA Tarhini, JR Eads, KN Moore… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Neoadjuvant Immunotherapy Working Group, this article summarizes the current state of
neoadjuvant immunotherapy … recommendations related to future neoadjuvant trial designs and …